Rora Gene Summary [Rat]
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | Rora |
| Official Name | RAR-related orphan receptor A [Source:RGD Symbol;Acc:1308419] |
| Ensembl ID | ENSRNOG00000027145 |
| Bio databases IDs | |
| Aliases | RAR-related orphan receptor A |
| Synonyms | 9530021D13RIK, Hs.560343, IDDECA, LOC100502669, LOC103693129, LOC283666, nmf267, NR1F1, Nuclear receptor ror alpha 1 homolog, Nuclear receptor ror α 1 homolog, RAR-related orphan receptor A, RAR-related orphan receptor alpha, RAR-related orphan receptor α, ROR1, ROR2, ROR3, ROR Alpha, Ror gamma, ROR α, Ror γ, RZRA, RZR-ALPHA, RZR-α, sg, staggerer, tmgc26 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rora often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- nucleic acid binding
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- beta-catenin binding
- alpha helix
- transcription factor binding
- AF-2 transcription activation domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- hinge domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
- CAD domain
Pathways
Biological processes and signaling networks where the Rora gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- acute myocardial infarction
- COVID-19
- schizophrenia
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- neoplasia
- experimental autoimmune encephalomyelitis
- cardiovascular disorder
role in cell
- expression in
- activation
- proliferation
- quantity
- apoptosis
- activation in
- migration
- number
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cellular membrane
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rora gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar granule cell precursor proliferation
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
- positive regulation of circadian rhythm
- regulation of smoothened signaling pathway
- circadian regulation of gene expression
- cGMP metabolic process
- positive regulation of transcription, DNA-dependent
- angiogenesis
- regulation of macrophage activation
- cellular response to tumor necrosis factor
- cellular response to hypoxia
- triglyceride homeostasis
- intracellular receptor mediated signaling pathway
- positive regulation vascular endothelial growth factor production
- cerebellar Purkinje cell differentiation
- negative regulation of inflammatory response
- negative regulation of fat cell differentiation
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- regulation of glucose metabolic process
- muscle cell differentiation
- xenobiotic metabolic process
- cellular response to interleukin-1
- nitric oxide biosynthetic process
- T-helper 17 cell differentiation
- regulation of steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- oxysterol binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding
- transcription corepressor binding
- DNA binding
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity