Lpo Gene Summary [Rat]
Predicted to enable thiocyanate peroxidase activity. Predicted to be involved in defense response to bacterium and detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in basolateral plasma membrane and cytoplasm. Predicted to be active in extracellular space. Orthologous to human LPO (lactoperoxidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpo |
| Official Name | lactoperoxidase [Source:RGD Symbol;Acc:1310051] |
| Ensembl ID | ENSRNOG00000008422 |
| Bio databases IDs | |
| Aliases | lactoperoxidase |
| Synonyms | 5830499B15Rik, lactoperoxidase, SPO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lpo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxidase
- peroxidase (miscellaneous)
- Animal haem peroxidase
- enzyme
- Animal heme peroxidases and related proteins
Pathways
Biological processes and signaling networks where the Lpo gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- dextran sodium sulfate-induced colitis
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- substance-related disorder
- attention deficit hyperactivity disorder
regulates
- nitric oxide
- reactive oxygen species
- hydrogen peroxide
- nitrite
- glutathionyl radical
- isoniazid
- LDL
- thiocyanate
- alpha tubulin
- L-methionine
role in cell
- cellular infiltration by
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lpo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- thiocyanate metabolic process
- detection of chemical stimulus involved in sensory perception of bitter taste
- defense response to bacterium
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- extracellular region
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- heme binding