Tsc1 Gene Summary [Rat]
Predicted to enable ATPase inhibitor activity; heat shock protein binding activity; and protein folding chaperone. Involved in several processes, including negative regulation of GTPase activity; positive regulation of stress fiber assembly; and regulation of macroautophagy. Located in growth cone; nucleus; and perinuclear region of cytoplasm. Used to study obesity. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsc1 |
| Official Name | TSC complex subunit 1 [Source:RGD Symbol;Acc:620124] |
| Ensembl ID | ENSRNOG00000011470 |
| Bio databases IDs | |
| Aliases | TSC complex subunit 1 |
| Synonyms | Hamartin, LAM, TSC, TSC complex subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tsc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- Domain of unknown function (DUF4515)
- Hsp70 protein binding
- Hamartin protein
- heat shock protein binding
- coiled-coil domain
- protein binding
- Tropomyosin
- Mechanosensitive ion channel porin domain
- Trichohyalin-plectin-homology domain
- ATPase inhibitor activity
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- chaperone binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Tsc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- obesity
- tumorigenesis
- urogenital cancer
- neoplasia
- liver cancer
- renal cancer
- renal clear cell adenocarcinoma
role in cell
- quantity
- expression in
- proliferation
- phosphorylation in
- activation in
- migration
- number
- differentiation
- response
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- cell periphery
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- basal bodies
- actin filaments
- lipid droplets
- cytosol
- lysosome membrane
- growth cone
- neurites
- cellular protrusions
- postsynaptic density
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tsc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of cell proliferation
- cell projection organization
- regulation of stress fiber assembly
- adult locomotory behavior
- myelination
- regulation of phosphoprotein phosphatase activity
- associative learning
- regulation of translation
- potassium ion transport
- response to insulin stimulus
- neural tube closure
- kidney development
- negative regulation of cell size
- regulation of cell cycle
- negative regulation of TOR signaling cascade
- negative regulation of translation
- cardiac muscle cell differentiation
- cell-matrix adhesion
- negative regulation of ATPase activity
- synapse organization
- adaptive immune response
- hippocampus development
- glucose import
- cellular response to starvation
- cerebral cortex development
- protein folding
- memory T cell differentiation
- ribosomal subunit export from nucleus
- positive regulation of focal adhesion assembly
- regulation of cell-matrix adhesion
- negative regulation of macroautophagy
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- actin filament
- plasma membrane
- lysosomal membrane
- lipid particle
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cell cortex
- membrane
- cytosol
- macromolecular complex
- TSC1-TSC2 complex
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- protein binding
- ATPase inhibitor activity
- chaperone binding
- Hsp90 protein binding
- Hsp70 protein binding