Kcnd1 Gene Summary [Rat]
Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnd1 |
| Official Name | potassium voltage-gated channel subfamily D member 1 [Source:RGD Symbol;Acc:621364] |
| Ensembl ID | ENSRNOG00000039544 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily D member 1 |
| Synonyms | 1110037K09Rik, Kca2-1, KV4.1, mShal1, potassium voltage-gated channel, Shal-related family, member 1, potassium voltage-gated channel subfamily D member 1, Shal, Shal1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- Domain of unknown function (DUF3399)
- Shal-type voltage-gated potassium channels, N-terminal
- A-type (transient outward) potassium channel
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- secondary progressive multiple sclerosis
- nonarteritic ischemic optic neuropathy
- primary progressive multiple sclerosis
- nerve injury
role in cell
- action potential in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- voltage-gated potassium channel complex
- dendritic spine
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- A-type (transient outward) potassium channel activity