Thrb Gene Summary [Rat]
Enables double-stranded DNA binding activity; identical protein binding activity; and nuclear receptor activity. Involved in several processes, including positive regulation of chondrocyte differentiation; positive regulation of ossification; and regulation of lipid metabolic process. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study breast cancer. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; prostate cancer; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thrb |
| Official Name | thyroid hormone receptor beta [Source:RGD Symbol;Acc:3858] |
| Ensembl ID | ENSRNOG00000006649 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor beta |
| Synonyms | C-ERBA-2, C-ERBA-BETA, C-ERBA-β, ERBA2, GRTH, NR1A2, PRTH, RATT3REC, T3R[b], T3Rbeta, T3rec, THR1, Thrb1, THRbeta, THRbeta1, Thrbeta2, thyroid hormone receptor beta, THYROID HORMONE receptor beta2, Thyroid hormone receptor β, TRb, TRbeta, TR β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Thrb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- A/B region
- transcription factor binding
- AF-2 transcription activation domain
- chromatin binding
- CoR box
- identical protein binding
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- P-box
- AF-1 domain
- ligand-binding domain
- ligand-dependent nuclear receptor
- corepressor binding domain
- a/b binding pocket
- hormone binding
- dimerization domain
- amphipathic helix
- DNA binding domain
- alpha helix
- enzyme binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- T3 binding domain
- double-stranded DNA binding
- hinge domain
- thyroid hormone receptor binding domain
- Ligand-binding domain of nuclear hormone receptor
- C-terminal extension
- transcription factor activity
Pathways
Biological processes and signaling networks where the Thrb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- metastasis
- advanced cancer
- cancer
- epithelial neoplasia
- adenoma formation
- head and neck neoplasia
- hypothyroidism
- lung cancer
role in cell
- number
- expression in
- proliferation
- growth
- quantity
- migration
- apoptosis
- transcription in
- phosphorylation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- myelin enriched fraction
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- basolateral membrane
- nucleoplasm
- nuclear bodies
- nuclear envelope
- chromatin
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Thrb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- female courtship behavior
- transcription, DNA-dependent
- regulation of heart contraction
- positive regulation of transcription from RNA polymerase II promoter
- thyroid hormone mediated signaling pathway
- retinal cone cell development
- negative regulation of female receptivity
- positive regulation of thyroid hormone mediated signaling pathway
- cellular response to thyroid hormone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- sensory perception of sound
- retinoic acid receptor signaling pathway
- Type I pneumocyte differentiation
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- DNA binding
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- thyroid hormone binding
- enzyme binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding