Il16

Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cytokine production; and positive regulation of inflammatory response. Predicted to act upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Predicted to be located in several cellular components, including Flemming body; focal adhesion; and nuclear speck. Biomarker of borna disease; glioblastoma; and periodontal disease. Human ortholog(s) of this gene implicated in asthma; colorectal adenocarcinoma; and prostate cancer. Orthologous to human IL16 (interleukin 16). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Il16 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Il16 gene, providing context for its role in the cell.