Hmga1 Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; catalytic activity, acting on DNA; and nuclear retinoid X receptor binding activity. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytosol; nucleus; and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmga1 |
| Official Name | high mobility group AT-hook 1 [Source:RGD Symbol;Acc:628699] |
| Ensembl ID | ENSRNOG00000000488 |
| Bio databases IDs | |
| Aliases | high mobility group AT-hook 1 |
| Synonyms | high mobility group AT-hook 1, HMG1(Y), Hmgi, HMGIY, HMG-I(Y), HMG-R, Hmgy, Hmg-y/i, LOC689053 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hmga1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- retinoic acid receptor binding
- DNA secondary structure binding
- transcription factor binding
- chromatin binding
- enzyme
- proline rich domain
- AT DNA binding
- structural constituent of chromatin
- peroxisome proliferator activated receptor binding
- tail domain
- DNA binding domain
- nucleic acid binding
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme binding
- DNA bending protein
- protein binding
- sequence-specific DNA binding
- carbon-oxygen lyase
- acidic domain
- DNA binding
- RNA binding
- double-stranded DNA binding
- AT hook domain
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the Hmga1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hyperplasia
- metastasis
- non-insulin-dependent diabetes mellitus
- cancer
- acute myeloid leukemia
- adenoma formation
- epithelial neoplasia
- head and neck neuroendocrine neoplasia
- head and neck neoplasia
role in cell
- apoptosis
- cell death
- expression in
- binding in
- growth
- proliferation
- phosphorylation in
- morphology
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- nuclear envelope
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hmga1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oncogene-induced senescence
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- nucleosome disassembly
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- focal adhesion
- cytosol
- senescence-associated heterochromatin focus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- DNA binding, bending
- AT DNA binding
- core promoter proximal region sequence-specific DNA binding
- chromatin binding
- retinoic acid receptor binding
- retinoid X receptor binding
- peroxisome proliferator activated receptor binding
- DNA binding
- transcription cofactor binding
- structural constituent of chromatin
- protein binding
- RNA binding
- transcription cofactor activity
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- binding, bridging
- enzyme binding