Details
| Type | Mitochondrial Transfer RNA |
| Official Symbol | MT-TI |
| Official Name | mitochondrially encoded tRNA-Ile (AUU/C) [Source:HGNC Symbol;Acc:HGNC:7488] |
| Ensembl ID | ENSG00000210100 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded tRNA-Ile (AUU/C) |
| Synonyms | mt-Ti-201, tRNA-Ile, TRNI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MT-TI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- triplet codon-amino acid adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- MELAS syndrome
- lethal cardiomyopathy
- diabetes mellitus
- myoclonus epilepsy and ragged red fibers syndrome
- cardiomyopathy
- familial hypertrophic cardiomyopathy
- mitochondrial hypertension, hypercholesterolemia, and hypomagnesemia
- mitochondrial disorder
- hypertrophic cardiomyopathy
- mitochondrially inherited nonsyndromic sensorineural deafness
regulated by
- MAF1
- bardoxolone methyl
role in cell
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria