MT-CO2 Gene Summary [Human]
Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and positive regulation of vasoconstriction. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Biomarker of Huntington's disease and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MT-CO2 |
| Official Name | mitochondrially encoded cytochrome c oxidase II [Source:HGNC Symbol;Acc:HGNC:7421] |
| Ensembl ID | ENSG00000198712 |
| Bio databases IDs | |
| Aliases | mitochondrially encoded cytochrome c oxidase II |
| Synonyms | CIV-II, Co2, COII, COX2, COX II, CYTC OXIDASE II, cytochrome c oxidase subunit II, CYTOCHROME OXIDASE subunit 2, CytOX II, Pil7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MT-CO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cupredoxin superfamily
- cytochrome c oxidase, subunit II
- Cytochrome C oxidase subunit II, transmembrane domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the MT-CO2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- primary gout
- gout
- chronic cough
- bleeding
- pain
- cardiovascular disorder
- rheumatoid arthritis
- osteoarthritis
- Alzheimer disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- cellular membrane
- Mitochondria
- Golgi membrane
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MT-CO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- mitochondrial electron transport, cytochrome c to oxygen
- lactation
- cellular respiration
- ATP synthesis coupled electron transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex IV
- membrane
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity
- protein binding
- copper ion binding