CDC42EP4

CDC42EP4 Gene Summary

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
CDC42EP4
Official Name
CDC42 effector protein 4 [Source:HGNC Symbol;Acc:HGNC:17147]
Ensembl ID
ENSG00000179604
Bio databases IDs NCBI: 23580 Ensembl: ENSG00000179604
Aliases CDC42 effector protein 4, Cdc42 effector protein 4, binder of Rho GTPases 4
Synonyms
1500041M20Rik,BORG4,CDC42 effector protein 4,CEP4,KAIA1777
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cdc42 effector
  • CRIB
  • protein binding

Pathways

Biological processes and signaling networks where the CDC42EP4 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • RTN4IP1
  • APP
  • RAC1
  • HRAS
  • SEPTIN9
  • TRAF5
  • SEPTIN6
  • SPRY2
  • SEPTIN14
  • OCLN
disease
  • frontal fibrosing alopecia
  • early missed abortion
regulated by
  • LH
  • FSH
  • lipopolysaccharide
  • IFNG
  • TNF
  • Pc 3 cells
  • OSM
  • TGFB1
  • L-triiodothyronine
  • PRKCA
regulates
  • RAC
role in cell
  • activation in
  • motility
  • formation
  • response by
  • formation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • microtubule cytoskeleton
  • cellular membrane
  • actin cytoskeleton
  • Plasma Membrane
  • cytosol
  • phagosomes
  • cell-cell adherens junctions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CDC42EP4 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • regulation of cell shape
  • positive regulation of pseudopodium assembly
  • positive regulation of actin filament polymerization
  • Rho protein signal transduction
  • cellular response to interferon-gamma

CELLULAR COMPONENT

Where in the cell the gene product is active
  • microtubule cytoskeleton
  • adherens junction
  • cytoskeleton
  • cytoplasm
  • phagocytic vesicle
  • actin cytoskeleton
  • cytosol
  • endomembrane system
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • RNA binding
  • small GTPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.