A3galt2 Gene Summary [Mouse]
Enables alpha-1,3-galactosyltransferase activity. Acts upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus and vesicle. Orthologous to human A3GALT2 (alpha 1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | A3galt2 |
| Official Name | alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) [Source:MGI Symbol;Acc:MGI:2685279] |
| Ensembl ID | ENSMUSG00000028794 |
| Bio databases IDs | |
| Aliases | alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) |
| Synonyms | A3GALT2P, alpha 1,3-galactosyltransferase 2, Gm433, iGb3, IGB3S, iGb3 synthase, IGBS3S, α 1,3-galactosyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse A3galt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- galactosyltransferase
- enzyme
- glycosyltransferase
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse A3galt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- glycosphingolipid biosynthetic process
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- vesicle
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- alpha-1,3-galactosyltransferase activity
- transferase activity, transferring glycosyl groups
- metal ion binding
- N-acetyllactosaminide 3-alpha-galactosyltransferase activity