A3GALT2 Gene Summary [Human]
Predicted to enable N-acetyllactosaminide 3-alpha-galactosyltransferase activity and alpha-1,3-galactosyltransferase activity. Predicted to be involved in lipid glycosylation. Predicted to act upstream of or within glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | A3GALT2 |
| Official Name | alpha 1,3-galactosyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:30005] |
| Ensembl ID | ENSG00000184389 |
| Bio databases IDs | |
| Aliases | alpha 1,3-galactosyltransferase 2, iGb3 synthase, isoglobotriaosylceramide synthase |
| Synonyms | A3GALT2P, alpha 1,3-galactosyltransferase 2, Gm433, iGb3, IGB3S, iGb3 synthase, IGBS3S, α 1,3-galactosyltransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human A3GALT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- galactosyltransferase
- enzyme
- glycosyltransferase
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human A3GALT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- glycosphingolipid biosynthetic process
- lipid glycosylation
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- vesicle
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- alpha-1,3-galactosyltransferase activity
- transferase activity, transferring glycosyl groups
- metal ion binding
- N-acetyllactosaminide 3-alpha-galactosyltransferase activity