Ifngr1 Gene Summary [Mouse]
Predicted to enable type II interferon receptor activity. Involved in glial cell activation; negative regulation of amyloid-beta clearance; and positive regulation of macromolecule metabolic process. Acts upstream of or within defense response to virus. Predicted to be located in dendrite and vesicle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; bone; cerebral cortex; female reproductive system; and liver. Used to study osteoporosis. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifngr1 |
| Official Name | interferon gamma receptor 1 [Source:MGI Symbol;Acc:MGI:107655] |
| Ensembl ID | ENSMUSG00000020009 |
| Bio databases IDs | |
| Aliases | interferon gamma receptor 1 |
| Synonyms | CD119, Ifgr, IFN-gammaR, IFN gamma R alpha, IFN-gamma receptor, IFNGR, Ifngra, IFN-γR1, IFN-γ receptor, IFN γ R α, IMD27A, IMD27B, interferon gamma receptor 1, INTERFERON gamma receptor alpha CHAIN, interferon γ receptor, interferon γ receptor 1, INTERFERON γ receptor α CHAIN, MAF receptor, Nktar |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifngr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- STAT binding domain
- extracellular domain
- STAT1 binding domain
- cytoplasmic domain
- interferon-gamma receptor
- transmembrane domain
- intracellular domain
- protein binding
- membrane-proximal domain
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Ifngr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Colorectal Cancer Metastasis Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- iNOS Signaling
- Interferon Signaling
- Neuroinflammation Signaling Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- tumorigenesis
- diabetes mellitus
- kidney disease
- infection by murine hepatitis virus
- lupus erythematosus
- autosomal recessive mycobacteriosis immunodeficiency 27A
- insulitis
role in cell
- adhesion
- activation in
- expression in
- phosphorylation in
- growth
- formation
- proliferation
- quantity
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- Cytoplasm
- cell surface
- cell periphery
- membrane surface
- cellular membrane
- vesicles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifngr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte activation
- microglial cell activation
- interferon-gamma-mediated signaling pathway
- signal transduction
- cytokine-mediated signaling pathway
- positive regulation of gene expression
- negative regulation of beta-amyloid clearance
- positive regulation of tumor necrosis factor production
- response to virus
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor activity
- cytokine binding
- cytokine receptor activity