Cyp3a23/3a1 Gene Summary [Rat]
Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in oxidative demethylation and xenobiotic metabolic process. Predicted to be located in cytoplasm. Used to study alcohol dependence and anxiety disorder. Biomarker of cholestasis and end stage renal disease. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp3a23/3a1 |
| Official Name | cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 [Source:RGD Symbol;Acc:628626] |
| Ensembl ID | ENSRNOG00000032560 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 |
| Synonyms | Cyp3a11, cytochrome P450, family 3, subfamily a, polypeptide 2, P-450ut-a |
| Species | Rat, Rattus norvegicus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp3a23/3a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxidoreductase
- enzyme binding
- iron ion binding
- enzyme
- steroid hydroxylase
- CH2 group oxidoreductase
- steroid binding
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- vitamin D3 25-hydroxylase
- reduced flavin or flavoprotein:oxygen oxidoreductase
- testosterone 6 beta-hydroxylase
- retinoic acid 4-hydroxylase
- monooxygenase
- demethylase activity
Pathways
Biological processes and signaling networks where the Cyp3a23/3a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CYP27B1
- RXR
disease
- chronic renal failure
regulated by
- sirolimus
- deoxycholate
- ketoconazole
- phenobarbital
- IFNG
- pantoprazole
- levothyroxine
- beta-naphthoflavone
- 3-methylcholanthrene
- L-glutamic acid
regulates
- testosterone
- reactive oxygen species
- docetaxel
- xenobiotic
- 3-keto lithocholic acid
- lithocholic acid
- paclitaxel
- 3,4-methylenedioxyamphetamine
- amiodarone
- desethylamiodarone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- microsome