Target List
Non Small Cell Lung Cancers (NSCLC)
ADGRB3, ALK, AMER1, APC, ATM, BRAF, CDKN2A (P16INK4A), CTNNB1, EGFR (ERBB1), ERBB2 (HER-2, NEU), FGFR3, GRM8, HRAS, JAK2, KRAS, MET, MUC16, NF1, NFE2L2, NRAS, NTRK2, NTRK3, PDGFRA, PIK3CA (p110-alpha), PIK3CG, PKHD1, PTEN, RB1, RET, SMARCA4, STK11 (LKB1), TNFAIP3, TP53 (p53)
Small Cell Lung Cancers
ADGRB3, ALK, AMER1, ARID1A, ATM, CDKN2A (P16INK4A), CREBBP (CBP), CTNNB1, DDR2, EGFR (ERBB1), EPHA5, ERBB4, FBXO7, FBXW7, FGFR1, FHIT, GRM8, HRAS, KDR (VEGFR3), KIT (CD117), KMT2D, KRAS, LRP1B, MET, MUC16, MYC, NF1, NOTCH1, NTRK1, NTRK2, NTRK3, PIK3CA (p110-alpha), PIK3CG, PIK3R1 (p85-ALPHA), PKHD1, PTEN, PTPRD, RARB, RB1, RBM10, RET, RIT1, ROS1, RUNX1T1, SETD2, SMARCA4, TNFAIP3, TP53 (p53)
Carcinomas
Acinar Adenocarcinomas
BRAF, EGFR (ERBB1), KRAS
Adenocarcinomas
ADGRB3, AKT1, ALK, AMER1, APC, ARID1A, ATM, BAP1, BRAF, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), CTNNB1, DDR2, EGFR (ERBB1), EPHA5, ERBB2 (HER-2, NEU), ERBB4, FBXO7, FBXW7, FGFR1, FGFR2, FGFR3, FHIT, GRM8, HRAS, JAK2, KDR (VEGFR3), KEAP1, KIT (CD117), KMT2D, KRAS, LRP1B, MAP2K1, MDM2, MET, MGA, MLH1, MUC16, MYC, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA (p110-alpha), PIK3CG, PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PKHD1, PTEN, PTPRD, RARB, RASSF1, RB1, RBM10, RET, RIT1, ROS1, RUNX1T1, SETD2, SMAD4 (MADH4), SMARCA4, SOX2, STK11 (LKB1), TNFAIP3, TP53 (p53), TSC1, U2AF1
Bronchioalveolar Adenocarcinomas
CDKN2A (P16INK4A), EGFR (ERBB1), ERBB2 (HER-2, NEU), KRAS, NF1, STK11 (LKB1), TP53 (p53)
Giant Cell Carcinomas
EGFR (ERBB1)
Large Cell Carcinomas
BRAF, CDKN2A (P16INK4A), DDR2, EGFR (ERBB1), EPHA5, FGFR1, FGFR3, HRAS, KEAP1, KRAS, NRAS, NTRK1, NTRK3, PIK3CA (p110-alpha), STK11 (LKB1), TP53 (p53)
Lymphoepithelioma-Like Carcinomas
EGFR (ERBB1), TP53 (p53)
Micropapillary Adenocarcinomas
BRAF, EGFR (ERBB1), KRAS
Mixed Adenosquamous Carcinomas
EGFR (ERBB1), KRAS, PIK3CA (p110-alpha), STK11 (LKB1), TP53 (p53)
Mixed Small Cell Carcinomas-Adenocarcinomas
CREBBP (CBP), DDR2, EGFR (ERBB1), TP53 (p53)
Mucoepidermoid Carcinomas
EGFR (ERBB1)
Oncocytic Adenocarcinomas
EGFR (ERBB1), KRAS
Other Carcinomas
ARID1A, CTNNB1, HRAS, NRAS
Pleomorphic Carcinomas
EGFR (ERBB1), KIT (CD117), KRAS, TP53 (p53)
Sarcomatoid Carcinomas
EGFR (ERBB1), KRAS
Squamous Cell Carcinomas (SCC)
ADGRB3, AKT1, ALK, AMER1, APC, ARID1A, ATM, BRAF, CDKN2A (P16INK4A), CDKN2B (p15INK4b), CREBBP (CBP), CTNNB1, DDR2, EGFR (ERBB1), EPHA5, ERBB2 (HER-2, NEU), ERBB4, FBXO7, FBXW7, FGFR1, FGFR2, FGFR3, FHIT, GRM8, HRAS, JAK2, KDR (VEGFR3), KEAP1, KIT (CD117), KMT2D, KRAS, LRP1B, MAP2K1, MDM2, MET, MGA, MLH1, MUC16, MYC, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PDGFRA, PIK3CA (p110-alpha), PIK3CG, PIK3R1 (p85-ALPHA), PIK3R2 (p85-BETA), PKHD1, PTEN, PTPRD, RARB, RB1, RBM10, RET, RIT1, ROS1, RUNX1T1, SETD2, SMAD4 (MADH4), SMARCA4, STK11 (LKB1), TNFAIP3, TP53 (p53), TSC1, U2AF1
Terminal Respiratory Unit Type Adenocarcinomas
EGFR (ERBB1)
Undifferentiated Carcinomas
EGFR (ERBB1), KRAS, MUC16, PKHD1, TP53 (p53)
Blastomas
CTNNB1, TP53 (p53)
Carcinoid-Endocrine Tumors
Atypical
KRAS, PIK3CA (p110-alpha), TP53 (p53)
Typical
PIK3CA (p110-alpha)
Carcinosarcomas
EGFR (ERBB1)
Other Cancer Subtypes
Hyperplasia
EGFR (ERBB1), KRAS
Mucinous Proliferation
KRAS
Neoplasms
EGFR (ERBB1), KRAS
Acinar Adenocarcinomas
ALK, CD74, EML4, HIP1, KIF5B, ROS1, SDC4
Adenocarcinomas
ALK, BAIAP2L1, BCL11A, BRAF, CCDC6, CD74, CUX1, EML4, EZR, FGFR2, FGFR3, GCC2, GOPC, HIP1, HLA-DRB1, KIAA1217, KIF5B, KLC1, LRIG3, MET, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NTRK2, PBX1, RET, ROS1, SDC4, SLC34A2, SND1, STARD3NL, STRN, TACC3, TCF3, TFG, TPM3, TPR, TRIM33
Bronchioloalveolar Adenocarcinomas
ALK, EML4, KLC1, PBX1, ROS1, SDC4, TCF3
Inflammatory Myofibroblastic Tumors
ALK, CD74, EML4, EZR, GOPC, LRIG3, ROS1, SDC4, SLC34A2, TPM3
Invasive Mucinous Adenocarcinomas
ALK, CD74, EML4, NRG1 (HGL), SLC3A2
Mixed Adenosquamous Carcinomas
ALK, EML4, KIF5B, RET
Mucoepidermoid Carcinomas
ALK, CRTC1, EML4, MAML2
Non-Small Cell Carcinomas
ALK, BCL11A, CCDC6, CD74, CUX1, EGFR (ERBB1), EML4, EZR, GCC2, GOPC, HIP1, KIAA1217, KIF5B, KLC1, LRIG3, NCOA4, RET, ROS1, SDC4, SLC34A2, STRN, TFG, TPM3, TPR, TRIM33
Non-Small Cell Lung Cancers (NSCLC)
ALK, BAG4, BAIAP2L1, BCL11A, CCDC6, CD74, CLIP4, CUX1, DNAH5, EGFR (ERBB1), EML4, ETV6, EZR, FER, FGFR1, FGFR3, GCC2, GLRX5, GOPC, HIP1, HLA-DRB1, IRF2BP2, KIAA1217, KIF5B, KLC1, LRIG3, MAN2A1, MET, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NTRK3, RAD51, RET, ROS1, RUNX1 (AML1), SDC4, SLC34A2, SLC3A2, SQSTM1, STRN, TACC3, TFG, TPM3, TPR, TRA2B, TRIM33, VSNL1
Squamous Cell Carcinomas (SCC)
ALK, BAIAP2L1, CD74, EML4, FGFR2, FGFR3, HIP1, KIF5B, NRG1 (HGL), RET, TACC3
Other Carcinomas
ALK, BRD4, EML4, NUTM1
Other Lung Cancers
ARL17A, BAG4, BAIAP2L1, CCDC6, CD74, CUX1, EZR, FGFR1, FGFR3, GOPC, IRF2BP2, KANSL1, KIAA1217, KIF5B, LRIG3, MPRIP, NCOA4, NRG1 (HGL), NTRK1, NUTM1, PTPRK, RET, ROS1, RSPO3, SDC4, SLC34A2, SLC3A2, SQSTM1, TACC3, TPM3, TPR, TRIM33, WHSC1L1