Target List
Acute Lymphoblastic Leukemia (ALL)
ASXL2, ATM, BRAF, CALR, CDKN2A (P16INK4A), CREBBP (CBP), CRLF2 (TSLPR), CSF3R (GM-CSFR), CTCF, DNM2, EGFR (ERBB1), EP300, FBXW7, GATA2, HNRNPK, HRAS, IKZF3, IL7R, KDM6A, KDR (VEGFR3), KMT2C, LRRC4, MAP2K1, MLH1, MSH2, MSH6, NOTCH1, NTRK3, PAX5, PDGFRA, PMS2, PRAMEF2, PTEN, RELN, SMARCB1, ABL1, ABL2 (ARG), ACTN4, AFF1, AFF3, AFF4, AGGF1, ASNS, ATF7IP, AUTS2, BCL9, BCR, BTBD18, CASC5, CREBBP (CBP), CRLF2 (TSLPR), CSF1R, DDX3X, EBF1, ELL, ELN, EML1, EP300, EPS15, ESRRB, ETV6, EWSR1, FGFR1, FGFR1OP, FLT3, FOXO4, FOXP1, FRYL, GAS7, GPHN, HLF, HNRNPUL1, INPP5D, JAK2, KMT2A, KMT2E, LNP1, MAML2, MEF2D, MLLT1, MLLT10, MLLT3, AFDN, MN1, MNX1, MYC, NCOA2, NOTCH1, NUP214, NUP98, P2RY8, PAX5, PBX1, PCM1, PDGFRB, PICALM, PML, PRDM16, RAP1GDS1, RARA, RCSD1, RUNX1 (AML1), SALL2, SET, SFPQ, SPI1, SSBP2, STIL, STMN1, TAF15, TAL1, TCF3, TCF7, TET1, USP9X, ZBTB16, ZMIZ1, ZMYM2, ZNF384, ZNF521
Acute Myeloid Leukemia (AML)
ANKRD26, ASXL1, ATM, BCOR, BCORL1, BIRC3 (c-IAP2), BRAF, C17orf97, CALR, CARD11, CBLC, CDKN2A (P16INK4A), CEBPA, CHEK2 (RAD53), CREBBP (CBP), CSF1R, CSF3R (GM-CSFR), CTCF, DAXX, DDX41, DNM2, DNMT1, ELANE, EP300, FLRT2, FLT3, GATA1, GATA2, HNRNPK, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK3, KDM6A, KDR (VEGFR3), KIT (CD117), KMT2A, KMT2C, KMT2D, KRAS, LRRC4, MAP2K1, MPL, MSH6, MYC, NBN, NOTCH1, NPM1, NRAS, NSD1, NTRK3, OR13H1, OR8B12, P2RY2, PBRM1, PCDHB1, PDGFRA, PHF6, PPM1D, PRAMEF2, PRPF8, PTEN, PTPN11, RAD21, RET, RUNX1 (AML1), SF1, SF3A1, SMARCB1, SMC1A, SMC3, SRP72, SRSF2, STAG2, STXBP2, U2AF1, U2AF2, WT1, ABI1, ABI2, ABL1, AFF1, AFF4, ALK, ANLN, ARHGAP26, ARHGEF12, BCOR, BCR, CASC5, CBFA2T3, CBFB, CBL, CCDC88C, CEP170B, CHD1, CHIC2, CREBBP (CBP), DAB2IP, DDX10, DEK, DHH, ELL, EP300, EPS15, ERG, ETV6, FGFR1, FIP1L1, FLNA, FNBP1, FOXO3, FOXO4, FRYL, FUS, GAS7, GATA1, GLIS2, GPHN, HAUS1, HOXA9, HOXC11, HOXC13, HOXD13, IRF2BP2, JAK2, KAT6A, KDM5A, KIAA1524, KMT2A, LASP1, LNP1, LPP, LYN, MAML2, MECOM, MKL1, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, AFDN, MLLT6, MN1, MNX1, MYB, MYH11, MYO1F, NCKIPSD, NCOA2, NF1, NPM1, NSD1, NTRK3, NUMA1, NUP214, NUP98, PBX1, PCM1, PDGFRA, PDGFRB, PDS5A, PHF23, PICALM, PML, PRDM16, PRRX1, PSIP1, PTPRR, RANBP2, RARA, RBM15, RHEBL1, RPL22, RPN1, RUNX1 (AML1), RUNX1T1, SARNP, SEPT2, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SORBS2, STAT5B, TAF15, TCF3, TET1, TFG, TOP1, TOP3A, TRIP11, UBA2, USP42, WHSC1L1, WTIP, ZBTB16, ZFYVE19, ZNF384
Chronic Lymphocytic Leukemia (CLL)
ADA, BIRC3 (c-IAP2), BLM, BRAF, CALR, CHEK2 (RAD53), CSF3R (GM-CSFR), KCNA4, KLHL6, KMT2C, MAP2K1, NBN, NPAT, NTRK3, OR13H1, OR8B12, PRAMEF2, SRP72, TAL1, TERT, TUBA3C, WAS, WRN, MYC, NOTCH1
Chronic Myeloid Leukemia (CML)
ABL1, CALR, CDKN2A (P16INK4A), CEBPA, CREBBP (CBP), CSF1R, CSF3R (GM-CSFR), FBXW7, GATA2, KDM6A, MSH2, MSH6, RB1, SMC1A, TP53 (p53), ABL1, BCR, CCDC88C, ETV6, JAK2, MECOM, MN1, NDE1, PCM1, PDGFRB, RUNX1 (AML1)
Chronic Myelomonocytic Leukemia (CMML)
CALR, CEBPA, CSF1R, CSF3R (GM-CSFR), HRAS, KMT2C, LUC7L2, SRSF2, CREBBP (CBP), ELL, ETV6, KMT2A, MN1
Chronic Neutrophilic Leukemia (CNL)
CALR, CSF3R (GM-CSFR)
Multiple Myeloma
ATM, BCL6, BCR, BIRC3 (c-IAP2), BRAF, CDKN2A (P16INK4A), CEBPA, EGFR (ERBB1), FBXW7, GJB3, HRAS, KDM6A, MYC, NOTCH1, PTEN, SH2D1A, SMARCB1
Myelodysplastic Syndromes (MDS)
ATRX, CALR, CDKN2A (P16INK4A), CEBPA, CSF1R, CSF3R (GM-CSFR), EP300, ETNK1, GNAS, HRAS, KDM6A, KMT2A, KMT2C, RAD21, RB1, SETBP1, SF1, SF3A1, SMC3, SRSF2, STAG2, U2AF1, U2AF2, XPO1, ZRSR2, ABL1, ACTN4, ALK, CASC5, CREBBP (CBP), DEK, ERG, ETV6, FRYL, FUS, HOXD13, JAK2, KMT2A, LNP1, MAML2, MECOM, MLF1, MN1, MNX1, NDE1, NPM1, NUP214, NUP98, PCM1, PDGFRB, PRDM16, PTPRR, RANBP2, RUNX1 (AML1), RUNX1T1, TOP1
Myeloid Malignancies
CBL, CBLB, DNMT3A, EED, ETV6, EZH2, PRPF40B, SUZ12, TET2, TP53 (p53)
Myeloproliferative Neoplasms (MPN)
ABL1, ASXL1, CALR, CSF1R, JAK2, JAK3, KAT6A, KRAS, MPL, NF1, NRAS, RB1, SETBP1, SF3B1, SH2B3, SRSF2, STAG2
Myelofibrosis
CALR, CHEK2 (RAD53), CSF1R, IDH1, IDH2, SRSF2
Other Myeloid Neoplasms
BRAF, CDKN2A (P16INK4A), CEBPA, FBXW7, HRAS, IKZF3, KLHDC8B, KMT2C, MSH6, NTRK3, PTEN, SRP72, TPMT
Other Myeloid Neoplasm Genes
BRCA1, BRCA2, BRINP3, CUX1, FAM47A, FAS, KCNK13, MYD88, PML, PRF1, SAXO2, STAT3, TERC, TNFRSF13B
Acute Leukemia of Ambiguous Lineage
ABL1, AFF1, BCR, CT45A2, ETV6, EWSR1, GPHN, KMT2A, MLLT10, MN1, NUP214, PBX1, SET, TCF3, ZNF384
Acute Lymphoblastic B Cell Leukemia
ABL1, ACTN4, AFF1, AFF3, AFF4, BCR, BTBD18, EPS15, ERG, ETV6, EWSR1, FUS, GAS7, JAK2, KMT2A, MAPRE1, MLLT1, NUP214, PAX5, PBX1, PCM1, RUNX1 (AML1), SET, SSBP2, TCF3, ZNF384
Acute Lymphoblastic T Cell Leukemia
ABL1, BCR, CASC5, ETV6, JAK2, KMT2A, MLLT1, MLLT10, AFDN, NOTCH1, NUP214, PBX1, RUNX1 (AML1), SET, STIL, TAL1, TCF3
Acute Monoblastic Leukemia
KMT2A, MLLT10, PICALM
B Cell Prolymphocytic Leukemia
MYC
Burkitt Leukemia
MYC
Lymphoblastic Leukemia
AFF1, KMT2A
Myeloproliferative Neoplasms
ABL1, ACSL6, BCR, ETV6, FGFR1, FGFR1OP, FIP1L1, FLT3, HOXA9, HOXD13, JAK2, LYN, MECOM, MLF1, MN1, NPM1, NUP98, PDGFRB, PSIP1, RARA, RUNX1 (AML1), TNIP1, ZMYM2
Plasma Cell Leukemia
MYC
T Cell Prolymphocytic Leukemia
MYC
T-Cell Acute Myelocytic Leukemia
KMT2A, MLLT10
Other Leukemias
IKZF3, PDCD1LG2, PRKG2, ROS1, SETD2