Target List
Up-Regulated During Epithelial-to-Mesenchymal Transition
AHNAK, BMP1, CALD1, CAMK2N1, CDH2 (N-Cadherin), COL1A2, COL3A1, COL5A2, FN1, FOXC2, GNG11, GSC, IGFBP4, ITGA5, ITGAV, MMP2, MMP3, MMP9, MSN, SERPINE1 (PAI-1), SNAI1 (SNAIL), SNAI2, SNAI3, SOX10, SPARC, STEAP1, TCF4, TIMP1, TMEFF1, TMEM132A, TWIST1, VCAN, VIM, VPS13A, WNT5A, WNT5B
Down-Regulated During Epithelial-to-Mesenchymal Transition
CAV2, CDH1 (E-Cadherin), DSP, FGFBP1, IL1RN, KRT19, MST1R (RON), NUDT13, OCLN, DESI1, RGS2, SPP1, TFPI2, TSPAN13
Differentiation & Development
AKT1, BMP1, BMP2, BMP7, COL3A1, COL5A2, CTNNB1, DSP, ERBB3, F11R, FOXC2, FZD7, GSC, JAG1, KRT14, MST1R (RON), NODAL, NOTCH1, PTP4A1, SMAD2 (MADH2), SNAI1 (SNAIL), SNAI2, SOX10, TGFB2, TGFB3, TMEFF1, TWIST1, VCAN, WNT11, WNT5A, WNT5B
Cell Morphogenesis
CTNNB1, FOXC2, JAG1, RAC1, SMAD2 (MADH2), SNAI1 (SNAIL), SOX10, TGFB1, TGFB2, TGFB3, TWIST1, WNT11, WNT5A
Cell Growth & Proliferation
AKT1, BMP1, BMP7, CAV2, CTNNB1, EGFR (ERBB1), ERBB3, FGFBP1, FOXC2, IGFBP4, ILK, JAG1, MST1R (RON), NODAL, PDGFRB, TGFB1, TGFB2, TGFB3, TIMP1, VCAN, ZEB1
Cell Migration & Motility
CALD1, CAV2, EGFR (ERBB1), FN1, ITGB1, JAG1, MSN, MST1R (RON), NODAL, PDGFRB, RAC1, STAT3, TGFB1, VIM
Cytoskeleton Regulators
CAV2, KRT7, MAP1B, PLEK2, RAC1, VIM
Extracellular Matrix (ECM) & Cell Adhesion Molecules
BMP1, BMP7, CDH1 (E-Cadherin), CDH2 (N-Cadherin), COL1A2, COL3A1, COL5A2, CTNNB1, DSC2, EGFR (ERBB1), ERBB3, F11R, FN1, FOXC2, ILK, ITGA5, ITGAV, ITGB1, MMP2, MMP3, MMP9, PTK2 (FAK), RAC1, SERPINE1 (PAI-1), SPP1, TGFB1, TGFB2, TIMP1, VCAN
Signal Transduction
Estrogen Receptor Signaling
CAV2, ESR1 (ERα), KRT19, TGFB3
G-Protein Coupled Receptor Signaling
AKT1, FZD7, GNG11, RAC1, RGS2
Integrin-Mediated Signaling
COL3A1, ILK, ITGA5, ITGAV, ITGB1, PTK2 (FAK)
Notch Signaling
FOXC2, JAG1, NOTCH1
Receptor Tyrosine Kinase Signaling
EGFR (ERBB1), ERBB3, PDGFRB, RGS2, SPARC
TGFβ / BMP Signaling
BMP1, BMP2, BMP7, COL3A1, SMAD2 (MADH2), TGFB1, TGFB2, TGFB3
WNT Signaling
CTNNB1, FZD7, GSK3B, WNT11, WNT5A, WNT5B
Transcription Factors
CTNNB1, ESR1 (ERα), FOXC2, GSC, NOTCH1, GEMIN2, SMAD2 (MADH2), SNAI2, SNAI3, SOX10, STAT3, TCF3, TCF4, TWIST1, ZEB1, ZEB2