Opcml Gene Summary [Rat]
Involved in negative regulation of glial cell proliferation; positive regulation of cell size; and positive regulation of synapse assembly. Located in apical dendrite; dendritic spine; and neuronal cell body. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Opcml |
| Official Name | opioid binding protein/cell adhesion molecule-like [Source:RGD Symbol;Acc:620635] |
| Ensembl ID | ENSRNOG00000023809 |
| Bio databases IDs | |
| Aliases | opioid binding protein/cell adhesion molecule-like |
| Synonyms | 2900075O15RIK, 3732419F12, AI844366, B930023M13RIK, C230027C17, Gm181, IGLON1, LOC100128095, OBCAM, OPCM, opioid binding protein/cell adhesion molecule-like |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Opcml often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- vesicoureteral reflux
- colorectal cancer
- venous thromboembolism
- major depression
- Crohn disease
- schizophrenia
- migraines
- anorexia nervosa
- metabolic syndrome X
role in cell
- growth
- expression in
- phosphorylation in
- invasion by
- migration
- proliferation
- recognition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- dendritic spines
- synaptic vesicles
- perikaryon
- postsynaptic density
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Opcml gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron recognition
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding