Raf1 Gene Summary [Rat]
Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Raf1 |
| Official Name | Raf-1 proto-oncogene, serine/threonine kinase [Source:RGD Symbol;Acc:3531] |
| Ensembl ID | ENSRNOG00000010153 |
| Bio databases IDs | |
| Aliases | Raf-1 proto-oncogene, serine/threonine kinase |
| Synonyms | 6430402F14Rik, CMD1NN, CRAF, Craf1, D830050J10Rik, leukaemiA ONCOGENE HOMOLOG1, LEUKEMIA ONCOGENE HOMOLOG1, NS5, Raf-1 proto-oncogene, serine/threonine kinase, v-Raf, v-raf-leukaemia viral oncogene 1, v-raf-leukemia viral oncogene 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Raf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- protein serine/threonine kinase
- protein kinase
- PKC phosphorylation site
- regulatory domain
- lipid binding domain
- ATP-binding domain
- ATP binding
- enzyme
- Protein kinase domain
- enzyme activator activity
- identical protein binding
- BXB domain
- dimer interface domain
- Ras-binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- serine phosphorylation site
- Tyrosine kinase, catalytic domain
- cysteine rich domain
- activation domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- Ral binding domain
- CR1 domain
- CR2 domain
- enzyme binding
- CR3 domain
- enzyme regulator activity
- protein binding
- phosphatidic acid binding domain
- prenylation site
- MAP kinase kinase kinase
- active-Ras binding domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- conserved domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- adenylate cyclase binding
- Raf-like Ras-binding domain
- Ubl1_cv_Nsp3_N-like
- serine threonine rich domain
- zinc finger domain
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Raf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- BMP signaling pathway
- Cancer Drug Resistance By Drug Efflux
- Chemokine Signaling
- CNTF Signaling
- EGF Signaling
- Ephrin A Signaling
- ErbB2-ErbB3 Signaling
- ErbB4 Signaling
- FGF Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- IL-2 Signaling
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
- Oncostatin M Signaling
- PAK Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- SPINK1 General Cancer Pathway
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- advanced non-small cell lung adenocarcinoma
- advanced non-small cell lung cancer
- nonalcoholic fatty liver disease
- epithelial neoplasia
- benign neoplasia
- metastatic colon cancer
- metastatic melanoma
- papillary thyroid cancer
- metastatic papillary thyroid carcinoma
role in cell
- differentiation
- production in
- expression in
- cell death
- accumulation in
- survival
- cell cycle progression
- apoptosis
- migration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- caveolae fraction
- membrane fraction
- mitochondrial fraction
- dendrite tip
- nuclear lipid microdomain
- perinuclear region
- cellular membrane
- filamentous network
- Nucleus
- Plasma Membrane
- centrosome
- Golgi Apparatus
- Mitochondria
- cytosol
- mitochondrial outer membrane
- spindle pole
- membrane rafts
- pseudopodia
- microvilli
- perikaryon
- dendrites
- clathrin-coated vesicles
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Raf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- Schwann cell development
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- ERBB2-ERBB3 signaling pathway
- intermediate filament cytoskeleton organization
- myelination
- induction of apoptosis via death domain receptors
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- face development
- thymus development
- MAPK cascade
- wound healing
- regulation of cell differentiation
- type B pancreatic cell proliferation
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- death-inducing signaling complex assembly
- apoptotic process
- somatic stem cell maintenance
- negative regulation of protein complex assembly
- response to muscle stretch
- activation of adenylate cyclase activity
- positive regulation of peptidyl-serine phosphorylation
- insulin secretion involved in cellular response to glucose stimulus
- interferon-gamma-mediated signaling pathway
- signal transduction
- insulin-like growth factor receptor signaling pathway
- regulation of apoptotic process
- positive regulation of MAPK cascade
- nerve growth factor receptor signaling pathway
- thyroid gland development
- negative regulation of apoptotic process
- regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
- pseudopodium
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- small GTPase binding
- protein kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- enzyme binding