Fmo2 Gene Summary [Rat]
Predicted to enable N,N-dimethylaniline monooxygenase activity. Predicted to be involved in several processes, including NADP metabolic process; toxin metabolic process; and xenobiotic metabolic process. Predicted to act upstream of or within energy homeostasis; negative regulation of fatty acid oxidation; and oxygen metabolic process. Predicted to be located in membrane. Orthologous to human FMO2 (flavin containing dimethylaniline monoxygenase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fmo2 |
| Official Name | flavin containing dimethylaniline monoxygenase 2 [Source:RGD Symbol;Acc:628600] |
| Ensembl ID | ENSRNOG00000003510 |
| Bio databases IDs | |
| Aliases | flavin containing dimethylaniline monoxygenase 2 |
| Synonyms | 2310008D08Rik, 2310042I22Rik, AW107733, flavin containing dimethylaniline monoxygenase 2, flavin containing monooxygenase 2, FMO1B1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fmo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NAD(P)-binding Rossmann-like domain
- monooxygenase
- enzyme
- Flavin-binding monooxygenase-like
- FAD-NAD(P)-binding
- dimethylaniline monooxygenase (N-oxide-forming)
Pathways
Biological processes and signaling networks where the Fmo2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
- microsome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fmo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organic acid metabolic process
- oxygen metabolic process
- negative regulation of fatty acid oxidation
- xenobiotic metabolic process
- NADP metabolic process
- energy homeostasis
- NADPH oxidation
- toxin metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- NADP binding
- flavin adenine dinucleotide binding
- hypotaurine dehydrogenase activity
- N,N-dimethylaniline monooxygenase activity