Gstm4 Gene Summary [Mouse]
Enables glutathione transferase activity. Acts upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol and intercellular bridge. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstm4 |
| Official Name | glutathione S-transferase, mu 4 [Source:MGI Symbol;Acc:MGI:95862] |
| Ensembl ID | ENSMUSG00000027890 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase, mu 4 |
| Synonyms | 1110004G14Rik, glutathione S-transferase, mu 4, Gstb-4, GSTM4-4, GSTM7-7 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gstm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme binding
- protein homodimerization
- enzyme
- leukotriene-C4 synthase
Pathways
Biological processes and signaling networks where the Gstm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- Gstm1
- CREB
regulates
- 1,2-epoxy-3-(p-nitrophenoxy)propane
- glutathione
- 1-chloro-2,4-dinitrobenzene
- 4-nitrobenzyl chloride
- 3,4-dichloronitrobenzene
- trans-4-phenylbut-3-en-2-one
- nitrobenzene
- xenobiotic
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic bridges
- cytosol