Socs1 Gene Summary [Mouse]
Enables kinase inhibitor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell differentiation and positive regulation of CD4-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; fat cell differentiation; and negative regulation of signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Socs1 |
| Official Name | suppressor of cytokine signaling 1 [Source:MGI Symbol;Acc:MGI:1354910] |
| Ensembl ID | ENSMUSG00000038037 |
| Bio databases IDs | |
| Aliases | suppressor of cytokine signaling 1 |
| Synonyms | AISIMD, CIS1, CISH1, Cish7, JAB, JBP, Sosc1, SSI-1, STAT INDUCED STAT INHIBITOR-1, suppressor of cytokine signaling 1, TIP-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Socs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pre-SH2 domain
- kinase inhibitory region domain
- protein kinase binding
- protein kinase inhibitor activity
- kinase inhibitor activity
- linker domain
- protein binding
- phosphotyrosine binding domain
- insulin-like growth factor receptor binding
- SOCS box
- extended SH2-subdomain
- elongin B/C binding domain
- SOCS domain
- Src homology 2 (SH2) domain
- SOCS
Pathways
Biological processes and signaling networks where the Socs1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-2 Signaling
- IL-4 Signaling
- IL-6 Signaling
- IL-7 Signaling Pathway
- Interferon Signaling
- JAK/Stat Signaling
- Prolactin Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- STAT3 Pathway
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Type I Diabetes Mellitus Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- neoplasia
- edema
- hypoglycemia
- diabetes mellitus
- metastasis
- breast cancer
- hepatocellular carcinoma
role in cell
- expression in
- differentiation
- invasion
- phosphorylation in
- activation in
- proliferation
- cell death
- degradation in
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic ribonucleoprotein granule
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Socs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol phosphorylation
- negative regulation of CD8-positive, alpha-beta T cell differentiation
- fat cell differentiation
- negative regulation of tyrosine phosphorylation of STAT protein
- negative regulation of insulin receptor signaling pathway
- negative regulation of JAK-STAT cascade
- JAK-STAT cascade
- positive regulation of regulatory T cell differentiation
- cellular response to amino acid stimulus
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- regulation of protein phosphorylation
- cytokine-mediated signaling pathway
- regulation of cytokine production
- intracellular signal transduction
- macrophage differentiation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytoplasm
- cytoplasmic vesicle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- kinase inhibitor activity
- 1-phosphatidylinositol-3-kinase regulator activity
- protein kinase inhibitor activity
- insulin-like growth factor receptor binding