Trim45 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of inflammatory response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to act upstream of or within bone development. Predicted to be located in cytosol and intercellular bridge. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human TRIM45 (tripartite motif containing 45). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim45 |
| Official Name | tripartite motif-containing 45 [Source:RGD Symbol;Acc:1309168] |
| Ensembl ID | ENSRNOG00000015347 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 45 |
| Synonyms | 4921530N01RIK, RNF99, tripartite motif-containing 45 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trim45 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Filamin/ABP280 repeat
- B-box-type zinc finger superfamily
- B-Box C-terminal domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- enzyme
- protein binding
- Filamin-type immunoglobulin domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
regulated by
- tetradecanoylphorbol acetate
- NR3C1
- epicatechin
role in cell
- degradation in
- expression in
- production in
- transmembrane potential
- necrosis
- transactivation in
- damage
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trim45 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- negative regulation of inflammatory response
- bone development
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding