Stat3 Gene Summary [Rat]
Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stat3 |
| Official Name | signal transducer and activator of transcription 3 [Source:RGD Symbol;Acc:3772] |
| Ensembl ID | ENSRNOG00000019742 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 3 |
| Synonyms | 1110034C02Rik, acute-phase response factor, ADMIO, ADMIO1, APRF, HIES, MGC16063, signal transducer and activator of transcription 3, Stat3 alpha isoform, Stat3 beta isoform, Stat3 delta, Stat3 α isoform, Stat3 β isoform, Stat3 δ |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- transcription regulator
- CCR chemokine receptor binding
- STAT protein, DNA binding domain
- C domain
- protein binding activity, bridging
- transcription activation domain
- transcription factor binding
- coiled-coil domain
- chromatin binding
- identical protein binding
- Sh3 domain binding motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- STAT protein, protein interaction domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- ligand-dependent nuclear receptor interactor
- acetylation site
- protein kinase binding
- DNA binding domain
- nucleic acid binding
- protein phosphatase binding
- alpha helix
- linker domain
- protein binding
- receptor binding
- Src-homology 2 binding domain
- sequence-specific DNA binding
- STAT protein, all-alpha domain
- DNA binding
- RNA binding
- phosphorylation site
- minimal transactivation domain
- double-stranded DNA binding
- protein homodimerization
- ERK phosphorylation site
- CAD domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Stat3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Myeloid Leukemia Signaling
- CD40 Signaling
- EGF Signaling
- Ephrin A Signaling
- ErbB2-ErbB3 Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- Growth Hormone Signaling
- IGF-1 Signaling
- IL-22 Signaling
- IL-6 Signaling
- JAK/Stat Signaling
- Leptin Signaling in Obesity
- Oncostatin M Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of PKR in Interferon Induction and Antiviral Response
- SPINK1 General Cancer Pathway
- T Helper Cell Differentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-Hodgkin disease
- lymphomagenesis
- cancer
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- prostate cancer
- chronic lymphocytic leukemia
- Waldenström macroglobulinemia
regulated by
- CYP3A4
- testosterone
- parthenolide
- metformin
- erlotinib
- D-glucose
- NCGC00186528
- insulin
- glutathione
- AGER
role in cell
- expression in
- activation in
- phosphorylation in
- binding in
- differentiation
- production in
- apoptosis
- response
- activity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- early endosomal fractions
- nuclear fraction
- raft fractions
- soluble fraction
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- nuclear lipid microdomain
- Cytoplasm
- cellular membrane
- focal adhesions
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nuclear foci
- nucleoplasm
- neuromuscular junctions
- growth cone
- synapse
- membrane rafts
- chromatin
- postsynaptic density
- axon terminals
- plasma
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-9-mediated signaling pathway
- interleukin-2-mediated signaling pathway
- interleukin-11-mediated signaling pathway
- transforming growth factor beta receptor signaling pathway
- positive regulation of erythrocyte differentiation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of angiogenesis
- JAK-STAT cascade
- inflammatory response
- negative regulation of primary miRNA processing
- positive regulation of transcription, DNA-dependent
- cellular response to leptin stimulus
- T-helper 17 cell lineage commitment
- energy homeostasis
- positive regulation of tumor necrosis factor production
- regulation of cell cycle
- positive regulation vascular endothelial growth factor production
- growth hormone receptor signaling pathway
- mRNA transcription from RNA polymerase II promoter
- JAK-STAT cascade involved in growth hormone signaling pathway
- leptin-mediated signaling pathway
- negative regulation of inflammatory response
- response to leptin stimulus
- response to peptide hormone stimulus
- negative regulation of gene expression
- positive regulation of interleukin-8 production
- eye photoreceptor cell differentiation
- positive regulation of gene expression
- protein import into nucleus
- negative regulation of autophagy
- glucose homeostasis
- response to estradiol stimulus
- cellular response to hormone stimulus
- sexual reproduction
- positive regulation of interleukin-6 production
- T-helper 17 type immune response
- positive regulation of cell migration
- cell proliferation
- retinal rod cell differentiation
- regulation of multicellular organism growth
- negative regulation of cell proliferation
- nervous system development
- negative regulation of glycolysis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- eating behavior
- negative regulation of transcription from RNA polymerase II promoter
- protein kinase B signaling cascade
- cytokine-mediated signaling pathway
- negative regulation of stem cell differentiation
- somatic stem cell maintenance
- interleukin-6-mediated signaling pathway
- phosphorylation
- negative regulation of neuron migration
- intracellular receptor mediated signaling pathway
- astrocyte differentiation
- signal transduction
- radial glial cell differentiation
- regulation of transcription, DNA-dependent
- defense response
- regulation of cell proliferation
- regulation of feeding behavior
- regulation of transcription from RNA polymerase II promoter
- temperature homeostasis
- cell differentiation
- interleukin-15-mediated signaling pathway
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein kinase binding
- identical protein binding
- protein homodimerization activity
- protein phosphatase binding
- signaling adaptor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- receptor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- primary miRNA binding