PDHA2 Gene Summary [Human]
Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in pyruvate metabolic process. Located in mitochondrion and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PDHA2 |
| Official Name | pyruvate dehydrogenase E1 subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:8807] |
| Ensembl ID | ENSG00000163114 |
| Bio databases IDs | |
| Aliases | pyruvate dehydrogenase E1 subunit alpha 2 |
| Synonyms | PDHAL, pyruvate dehydrogenase E1 alpha 2, pyruvate dehydrogenase E1 subunit alpha 2, pyruvate dehydrogenase E1 subunit α 2, pyruvate dehydrogenase E1 α 2, SPGF70 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDHA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPP_enzymes
- Dehydrogenase E1 component
- enzyme
- protein binding
- pyruvate dehydrogenase (lipoamide)
- pyruvate dehydrogenase E1 component, alpha subunit
- aldehyde or oxo group:NAD or NADP oxidoreductase
- pyruvate dehydrogenase
Pathways
Biological processes and signaling networks where the PDHA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDHA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acetyl-CoA biosynthetic process from pyruvate
- tricarboxylic acid cycle
- glucose metabolic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- mitochondrion
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- pyruvate dehydrogenase (acetyl-transferring) activity
- pyruvate dehydrogenase (NAD+) activity