CUL3
CUL3 Gene Summary
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | CUL3 |
| Official Name | cullin 3 [Source:HGNC Symbol;Acc:HGNC:2553] |
| Ensembl ID | ENSG00000036257 |
| Bio databases IDs | |
| Aliases | cullin 3 |
| Synonyms | cullin 3,KIAA0617,NEDAUS,PHA2E |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- ubiquitin protein ligase activity
- protein binding activity, bridging
- Cullin protein neddylation domain
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- cyclin binding
- ubiquitin-protein transferase activity
- Cullin family
- Cullin
- notch binding
Pathways
Biological processes and signaling networks where the CUL3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- ALB
- GRIN3A
- GRIN1
- GRIN2D
- TTK
- GRIN2C
- GPNMB
- CHD4
- CUL3
disease
- schizophrenia
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- pseudohypoaldosteronism type IIE
- neurodevelopmental disorder with or without autism or seizures
- lung squamous cell carcinoma
- squamous cell lung cancer
- complex neurodevelopmental disorder
regulated by
- tetradecanoylphorbol acetate
- ID1
- imatinib
- KLHL12
- KEAP1
- CUL3
- KLHL21
- ATG16L1
- DI-1548
- ASPM
regulates
- AKT
- CCND1
- cholesterol
- IL6
- DNA promoter
- DNA endogenous promoter
- TH
- STAT3
- CCNE1
- RAS
role in cell
- replication in
- cell cycle progression
- apoptosis
- proliferation
- expression in
- migration
- cell viability
- degradation in
- ubiquitination in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- Plasma Membrane
- centrosome
- Golgi Apparatus
- cytosol
- nucleosomes
- nucleoplasm
- spindle pole
- nuclear scaffolds
- nuclear speckles
- sperm tail
- polar microtubule
- mitotic spindle
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CUL3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- embryonic cleavage
- negative regulation of Rho protein signal transduction
- regulation of cellular response to insulin stimulus
- cell projection organization
- positive regulation of cell proliferation
- positive regulation of mitotic metaphase/anaphase transition
- intrinsic apoptotic signaling pathway
- stress fiber assembly
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to amino acid stimulus
- inflammatory response
- integrin-mediated signaling pathway
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- G1/S transition of mitotic cell cycle
- positive regulation of protein ubiquitination
- Wnt receptor signaling pathway
- stem cell division
- cell migration
- positive regulation of cytokinesis
- protein autoubiquitination
- negative regulation of type I interferon production
- protein K48-linked ubiquitination
- protein polyubiquitination
- fibroblast apoptotic process
- protein monoubiquitination
- COPII vesicle coating
- gastrulation
- ubiquitin-dependent protein catabolic process
- protein destabilization
- ER to Golgi vesicle-mediated transport
- proteasomal ubiquitin-dependent protein catabolic process
- trophectodermal cellular morphogenesis
- liver morphogenesis
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- gene expression
- mitotic metaphase plate congression
- protein ubiquitination
CELLULAR COMPONENT
Where in the cell the gene product is active
- spindle pole
- Golgi apparatus
- plasma membrane
- nucleoplasm
- nucleus
- centrosome
- extracellular vesicular exosome
- mitotic spindle
- cytoplasm
- polar microtubule
- membrane
- cytosol
- Cul3-RING ubiquitin ligase complex
- sperm flagellum
MOLECULAR FUNCTION
What the gene product does at the molecular level
- POZ domain binding
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- Notch binding
- cyclin binding