CREM Gene Summary [Human]
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CREM |
| Official Name | cAMP responsive element modulator [Source:HGNC Symbol;Acc:HGNC:2352] |
| Ensembl ID | ENSG00000095794 |
| Bio databases IDs | |
| Aliases | cAMP responsive element modulator |
| Synonyms | cAMP responsive element modulator, CREM1, CREM-2, Crem α, Crem β, Crem γ, Crem ε, hCREM-2, ICER, Icer-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CREM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Basic region leucine zipper
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- leucine-charged residue-rich domains
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- pKID domain
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the CREM gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- hyperactive behavior
- epileptic seizure
- Crohn disease
- kindling
- inflammatory bowel disease
- fibrosis
- oligozoospermia
- teratozoospermia
- T-cell non-Hodgkin disease
role in cell
- growth
- expression in
- proliferation
- morphology
- G1 phase
- activation in
- cell death
- apoptosis
- production in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CREM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- rhythmic process
- signal transduction
- spermatogenesis
- cell differentiation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- glycosphingolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding protein binding
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity