BACE1-AS Gene Summary [Human]
This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer's disease. [provided by RefSeq, Jan 2015]
Details
| Type | Retained Intron |
| Official Symbol | BACE1-AS |
| Official Name | BACE1 antisense RNA [Source:HGNC Symbol;Acc:HGNC:37125] |
| Ensembl ID | ENSG00000278768 |
| Bio databases IDs | |
| Aliases | BACE1 antisense RNA, non-protein coding RNA 177 |
| Synonyms | BACE1 antisense RNA, BACE1-AS1, NCRNA00177 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- sporadic inclusion body myositis
- metastasis
- organismal death
- gastric cancer
regulated by
- D-glucose
- hydrogen peroxide
- mir-214 (includes others)
- APP
- 293 cells
- thapsigargin
- tunicamycin
role in cell
- expression in
- phosphorylation in
- migration
- production in
- invasion by
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown