MYC
MYC Gene Summary
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | MYC |
| Official Name | MYC proto-oncogene, bHLH transcription factor [Source:HGNC Symbol;Acc:HGNC:7553] |
| Ensembl ID | ENSG00000136997 |
| Bio databases IDs | |
| Aliases | MYC proto-oncogene, bHLH transcription factor |
| Synonyms | bHLHe39,CMYC,C-MYC-P64,mMyc,MRTL,Myc2,MYCC,MYC eRNA,MYC proto-oncogene, bHLH transcription factor,myelocytomatosis oncogene,Niard,Nird,RNCMYC |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- regulatory domain
- Myc leucine zipper domain
- transcription activation domain
- transcription factor binding
- Myc amino-terminal region
- leucine zipper domain
- identical protein binding
- Myc box II
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Box I domain
- basic helix-loop-helix-leucine zipper domain
- Box II domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- Acidic casein kinase ii consensus phosphorylation site
- basic domain
- Myc box I
- ubiquitin protein ligase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- dimerization domain
- Myc box IV
- DNA binding domain
- Pak2 phosphorylation site
- nucleic acid binding
- mRNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- nuclear localization sequence
- helical domain
- central domain
- protein binding
- sequence-specific DNA binding
- antigenic epitope
- acidic domain
- DNA binding
- phosphorylation site
- PEST domain
- conserved domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- binding protein
- double-stranded DNA binding
- NDB domain
- helix loop helix domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the MYC gene plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Autophagy
- Bladder Cancer Signaling
- DNA Methylation and Transcriptional Repression Signaling
- EIF2 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- ErbB2-ErbB3 Signaling
- ERK5 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-7 Signaling Pathway
- Mouse Embryonic Stem Cell Pluripotency
- Myc Mediated Apoptosis Signaling
- Neuregulin Signaling
- PDGF Signaling
- Polyamine Regulation in Colon Cancer
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Thyroid Cancer Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- IMPDH2
- FGFR3
- AXL
- ARID1A
- MAX
- PHC2
- SRP68
- ATG4B
- RBM7
- MRPL13
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- non-small cell lung cancer
- non-small cell lung carcinoma
- lung squamous cell carcinoma
- biliary tract cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- lymphoma
regulated by
- cisplatin
- oxaliplatin
- POU2F2
- dithiothreitol
- verapamil
- metformin
- dexamethasone
- AICDA
- tetradecanoylphorbol acetate
- sirolimus
regulates
- CXCL10
- JUN
- double-stranded DNA
- ADSL
- CXCL8
- RELA
- CCL5
- BCL2L1
- VEGFA
- TP53
role in cell
- cell viability
- expression in
- breakage in
- cell death
- apoptosis
- alternative splicing in
- proliferation
- survival
- quantity
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent-insoluble fractions
- spindle apparatus
- Cytoplasm
- perinuclear region
- centrosome
- Mitochondria
- microtubules
- cytosol
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear envelope
- nuclear matrix
- rough endoplasmatic reticulum
- chromatin
- axons
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MYC gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- response to growth factor stimulus
- positive regulation of cell proliferation
- positive regulation of metanephric cap mesenchymal cell proliferation
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- cellular iron ion homeostasis
- MAPK cascade
- chromatin remodeling
- negative regulation of fibroblast proliferation
- negative regulation of cell division
- positive regulation of transcription, DNA-dependent
- positive regulation of fibroblast proliferation
- G1/S transition of mitotic cell cycle
- cellular response to UV
- cellular response to hypoxia
- protein-DNA complex disassembly
- response to gamma radiation
- positive regulation of epithelial cell proliferation
- regulation of telomere maintenance
- positive regulation of mesenchymal cell proliferation
- hypermethylation of CpG island
- fibroblast apoptotic process
- response to DNA damage stimulus
- negative regulation of monocyte differentiation
- negative regulation of transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- ERK1 and ERK2 cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of telomerase activity
- chromosome organization
- branching involved in ureteric bud morphogenesis
- negative regulation of apoptotic process
- positive regulation of gene expression
- regulation of gene expression
- negative regulation of stress-activated MAPK cascade
- cellular response to xenobiotic stimulus
- regulation of cell cycle process
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- nucleolus
- chromatin
- Myc-Max complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- transcription cofactor binding
- DNA binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity