NANOG Gene Summary [Human]
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | NANOG |
| Official Name | Nanog homeobox [Source:HGNC Symbol;Acc:HGNC:20857] |
| Ensembl ID | ENSG00000111704 |
| Bio databases IDs | |
| Aliases | Nanog homeobox |
| Synonyms | 2410002E02Rik, ecat4, ENK, LOC100038891, LOC100293888, NANOG1, Nanog homeobox, Stm1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NANOG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- histone binding
- transcription regulator
- CD2 transactivation domain
- tryptophan rich domain
- nucleic acid binding
- protein binding activity, bridging
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the NANOG gene in human plays a role, providing insight into its function and relevance in health or disease.
- Embryonic Stem Cell Differentiation into Cardiac Lineages
- FAK Signaling
- Human Embryonic Stem Cell Pluripotency
- Mouse Embryonic Stem Cell Pluripotency
- PI3K/AKT Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma cancer
- brain cancer
- metastasis
- germ cell neoplasia
- placenta accreta spectrum
- glioblastoma
- tumorigenesis
- medulloblastoma
role in cell
- activation in
- proliferation
- formation
- formation in
- phosphorylation in
- expression in
- growth
- production in
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- perinuclear vesicles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NANOG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- stem cell maintenance
- regulation of cell differentiation
- positive regulation of stem cell proliferation
- endodermal cell fate specification
- regulation of gene expression
- cell differentiation
- somatic stem cell maintenance
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity