GSK3B Gene Summary [Human]
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | GSK3B |
| Official Name | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] |
| Ensembl ID | ENSG00000082701 |
| Bio databases IDs | |
| Aliases | glycogen synthase kinase 3 beta |
| Synonyms | 7330414F15Rik, 8430431H08Rik, glycogen synthase kinase 3 beta, glycogen synthase kinase 3 β, GSK-3, GSK-3beta, GSK-3β, Gsk-beta, Gsk-β, Tpk1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSK3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- ATP-binding domain
- ATP binding
- priming phosphorylation binding site
- transcription factor binding
- Protein kinase domain
- cytoskeletal protein binding
- tau protein binding
- Tyrosine kinase, catalytic domain
- ubiquitin protein ligase binding
- protein kinase A binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- Akt phosphorylation site
- protease binding
- catalytic domain
- beta-catenin binding
- NF-kappaB binding
- nuclear localization sequence
- protein binding
- p53 binding
- ionotropic glutamate receptor binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Tau-protein kinase
- binding protein
- Protein Kinases, catalytic domain
- integrin binding
- substrate binding domain
Pathways
Biological processes and signaling networks where the GSK3B gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Liver Signaling Pathway
- Cyclins and Cell Cycle Regulation
- Docosahexaenoic Acid (DHA) Signaling
- Endometrial Cancer Signaling
- ErbB2-ErbB3 Signaling
- GP6 Signaling Pathway
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-7 Signaling Pathway
- Integrin Signaling
- Mouse Embryonic Stem Cell Pluripotency
- NF-κB Signaling
- p53 Signaling
- Polyamine Regulation in Colon Cancer
- Prostate Cancer Signaling
- Reelin Signaling in Neurons
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Sonic Hedgehog Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- epithelial cancer
- neoplasia
- diabetes mellitus
- fibrosis
- insulin resistance
- tumorigenesis
- reperfusion injury
- preeclampsia
role in cell
- production in
- phosphorylation in
- expression in
- growth
- apoptosis
- replication in
- chemotaxis
- migration
- activation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- tip of neurite-like extensions
- glutaminergic synapse
- organelle
- Cytoplasm
- perinuclear region
- cellular membrane
- focal adhesions
- Plasma Membrane
- centrosome
- lysosome
- Mitochondria
- microtubules
- cytosol
- vesicle membrane
- nucleoplasm
- nuclear bodies
- dendritic spines
- growth cone
- synapse
- neuritic shafts
- early endosomes
- actin stress fibers
- beta-granules
- membrane rafts
- filopodia
- cell membrane leading edge
- meiotic spindles
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- apical processes
- vesicle fraction
- cytoskeletal fraction
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSK3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- dopamine receptor signaling pathway
- protein autophosphorylation
- positive regulation of flagellum assembly
- positive regulation of GTPase activity
- viral protein processing
- positive regulation of protein ubiquitination
- negative regulation of calcineurin-NFAT signaling cascade
- regulation of neuron projection development
- negative regulation of type B pancreatic cell development
- negative regulation of TOR signaling cascade
- intracellular signal transduction
- regulation of microtubule-based process
- negative regulation of protein localization to nucleus
- regulation of excitatory postsynaptic membrane potential
- positive regulation of protein export from nucleus
- positive regulation of protein catabolic process
- circadian rhythm
- regulation of protein export from nucleus
- negative regulation of gene expression
- positive regulation of autophagy
- negative regulation of phosphoprotein phosphatase activity
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of cell-matrix adhesion
- positive regulation of gene expression
- maintenance of cell polarity
- epithelial to mesenchymal transition
- establishment of cell polarity
- peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of cell migration
- peptidyl-threonine phosphorylation
- regulation of microtubule cytoskeleton organization
- regulation of long-term synaptic potentiation
- insulin receptor signaling pathway
- regulation of cellular response to heat
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- regulation of circadian rhythm
- protein phosphorylation
- ER overload response
- regulation of dendrite morphogenesis
- negative regulation of osteoblast differentiation
- regulation of axonogenesis
- negative regulation of protein complex assembly
- canonical Wnt receptor signaling pathway
- positive regulation of protein complex assembly
- neuron projection development
- negative regulation of glycogen biosynthetic process
- hippocampus development
- positive regulation of cell differentiation
- mitochondrion organization
- negative regulation of canonical Wnt receptor signaling pathway
- regulation of axon extension
- glycogen metabolic process
- cellular response to retinoic acid
- negative regulation of apoptotic process
- cell differentiation
- cellular response to interleukin-3
- superior temporal gyrus development
- negative regulation of glycogen (starch) synthase activity
- negative regulation of mesenchymal stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- dendrite
- centrosome
- cytoplasm
- mitochondrion
- cytosol
- plasma membrane
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- dynactin binding
- protease binding
- protein kinase activity
- beta-catenin binding
- protein serine/threonine kinase activity
- NF-kappaB binding
- tau-protein kinase activity
- ATP binding
- p53 binding
- protein binding
- ubiquitin protein ligase binding
- tau protein binding
- protein kinase A catalytic subunit binding
- kinase activity