Tacr3 Gene Summary [Rat]
Enables tachykinin receptor activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; regulation of dopamine metabolic process; and response to estradiol. Located in dendrite membrane and neuronal cell body membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tacr3 |
| Official Name | tachykinin receptor 3 [Source:RGD Symbol;Acc:3810] |
| Ensembl ID | ENSRNOG00000009372 |
| Bio databases IDs | |
| Aliases | tachykinin receptor 3 |
| Synonyms | HH11, K1R, NEUROKININ receptor NK3, NK3, NK-3R, NKR, Nmkr, TAC3R, TAC3RL, tachykinin receptor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tacr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- tachykinin receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tacr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- pervasive developmental disorder
- hypogonadotropic hypogonadism 11 without anosmia
- hot flashes
- hypogonadotropic hypogonadism 7
- weight gain
- hypogonadotropic hypogonadism
- Kallmann syndrome type 11
- delayed puberty
- bladder cancer
regulates
- Ca2+
- GNRH
- FSH
- dopamine
- LH
role in cell
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- sperm midpiece
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tacr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- positive regulation of uterine smooth muscle contraction
- regulation of dopamine metabolic process
- response to estradiol stimulus
- response to cocaine
- tachykinin receptor signaling pathway
- regulation of feeding behavior
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- sperm midpiece
- neuronal cell body membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tachykinin receptor activity