Tac3 Gene Summary [Rat]
Predicted to enable neuromedin K receptor binding activity and substance K receptor binding activity. Involved in positive regulation of blood pressure. Predicted to be located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 10 with or without anosmia. Orthologous to human TAC3 (tachykinin precursor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tac3 |
| Official Name | tachykinin precursor 3 [Source:RGD Symbol;Acc:3809] |
| Ensembl ID | ENSRNOG00000004229 |
| Bio databases IDs | |
| Aliases | tachykinin precursor 3 |
| Synonyms | HH10, LncZBTB39, NEUROKININ B, Neurokinin Beta, Neurokinin β, NK3, NKB, NKKB, NKNB, PPT-B, PRO1155, Tac2, tachykinin 2, Tachykinin B, tachykinin precursor 3, ZNEUROK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tac3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- coiled-coil domain
- Neurokinin B
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kallmann syndrome type 10
- infertility condition
- hot flashes
- amnesia
- delayed puberty
- early-onset preeclampsia
- hypogonadotropic hypogonadism 7
- hypogonadotropic hypogonadism 10 without anosmia
regulated by
- Influenza A virus (A/Puerto Rico/8/34(H1N1))
- ESR1
- beta-estradiol
- cisplatin
- estradiol-17beta-benzoate
- erythroid cells
- Ca2+
- testosterone
- dihydrotestosterone
- estrogen
role in cell
- proliferation
- firing
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- Plasma Membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tac3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- female pregnancy
- tachykinin receptor signaling pathway
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding