Foxa1 Gene Summary [Rat]
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of hydrogen peroxide-mediated programmed cell death and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in fibrillar center; microvillus; and nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxa1 |
| Official Name | forkhead box A1 [Source:RGD Symbol;Acc:2807] |
| Ensembl ID | ENSRNOG00000009284 |
| Bio databases IDs | |
| Aliases | forkhead box A1 |
| Synonyms | forkhead box A1, HNF3A, HNF3 alpha, HNF3 α, TCF3A, Transcription Factor 3a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Foxa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Forkhead domain
- FORKHEAD
- HNF3 C-terminal domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
- Forkhead N-terminal region
Pathways
Biological processes and signaling networks where the Foxa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- breast adenocarcinoma
- metastasis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- organismal death
- anhidrosis
- urothelial bladder carcinoma
- transitional cell bladder cancer
role in cell
- migration
- expression in
- proliferation
- apoptosis
- upregulation in
- binding in
- growth
- differentiation
- quantity
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- nucleoplasm
- microvilli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Foxa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial tube branching involved in lung morphogenesis
- lung epithelial cell differentiation
- prostate gland epithelium morphogenesis
- anatomical structure morphogenesis
- secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
- positive regulation of sequence-specific DNA binding transcription factor activity
- prostate gland stromal morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- epithelial cell maturation involved in prostate gland development
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of epithelial to mesenchymal transition
- neuron fate specification
- alveolar secondary septum development
- dorsal/ventral neural tube patterning
- smoothened signaling pathway
- anatomical structure formation involved in morphogenesis
- hormone metabolic process
- positive regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- dopaminergic neuron differentiation
- mesenchymal-epithelial cell signaling involved in prostate gland development
- positive regulation of apoptotic process
- glucose homeostasis
- positive regulation of smoothened signaling pathway
- response to estradiol stimulus
- positive regulation of intracellular estrogen receptor signaling pathway
- cell differentiation
- positive regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- nucleus
- microvillus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity