Gtf3c1 Gene Summary [Mouse]
Predicted to enable DNA binding activity and RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Part of ribonucleoprotein complex. Is expressed in central nervous system; genitourinary system; and submandibular gland primordium. Orthologous to human GTF3C1 (general transcription factor IIIC subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf3c1 |
| Official Name | general transcription factor III C 1 [Source:MGI Symbol;Acc:MGI:107887] |
| Ensembl ID | ENSMUSG00000032777 |
| Bio databases IDs | |
| Aliases | general transcription factor III C 1 |
| Synonyms | general transcription factor III C 1, general transcription factor IIIC subunit 1, LOC102554566, TF3C-alpha, TF3C-α, TFIIIC, TFIIIC220, TFIIICalpha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtf3c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HTH_ARSR
- protein binding
Pathways
Biological processes and signaling networks where the Gtf3c1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtf3c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- 5S class rRNA transcription from RNA polymerase III type 1 promoter
- rRNA transcription
- tRNA transcription from RNA polymerase III promoter
- tRNA transcription
Cellular Component
Where in the cell the gene product is active
- membrane
- transcription factor TFIIIC complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- core RNA polymerase III binding transcription factor activity