Fbl Gene Summary [Mouse]
Enables RNA binding activity. Acts upstream of or within sno(s)RNA metabolic process. Located in Cajal body and granular component. Is expressed in several structures, including central nervous system; early embryo; oocyte; retina; and submandibular gland primordium. Orthologous to human FBL (fibrillarin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbl |
| Official Name | fibrillarin [Source:MGI Symbol;Acc:MGI:95486] |
| Ensembl ID | ENSMUSG00000046865 |
| Bio databases IDs | |
| Aliases | fibrillarin |
| Synonyms | FIB, fibrillarin, FLRN, Nop1, RNU3IP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif
- alpha helix
- transcription factor binding
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- RNA binding
- protein methyltransferase
- ATPase binding
- histone methyltransferase
- binding protein
- Fibrillarin
- glycine arginine rich domain
- RNA-binding domain
- N-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- Huntington disease
- colon epithelial cancer
- colon adenocarcinoma
- systemic autoimmune syndrome
- septic shock
- infection by vesicular stomatitis virus
regulates
- NFkB (complex)
- Gm22357
role in cell
- cell viability
- apoptosis
- activation in
- damage in
- base-excision repair in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleolar fraction
- fibrillar center
- pre-ribosome
- metaphase plate
- granular components
- gems
- dense fibrillar component
- chromosome
- inner nuclear membrane
- nucleoplasm
- nucleolus derived foci
- nucleoli
- coiled body
- Cajal bodies
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snoRNA localization
- chromatin remodeling
- box C/D snoRNA 3'-end processing
- ribosomal small subunit biogenesis
- rRNA methylation
- osteoblast differentiation
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- box C/D snoRNP complex
- granular component
- nucleus
- small-subunit processome
- extracellular vesicular exosome
- membrane
- Cajal body
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- rRNA methyltransferase activity
- RNA binding
- protein binding
- TFIID-class transcription factor binding
- ATPase binding