Ep300 Gene Summary [Mouse]
Enables several functions, including N-acyltransferase activity; p53 binding activity; and transcription coactivator activity. Involved in several processes, including face morphogenesis; protein acylation; and protein stabilization. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and somitogenesis. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including early conceptus; eye; heart; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ep300 |
| Official Name | E1A binding protein p300 [Source:MGI Symbol;Acc:MGI:1276116] |
| Ensembl ID | ENSMUSG00000055024 |
| Bio databases IDs | |
| Aliases | E1A binding protein p300 |
| Synonyms | A430090G16, A730011L11, E1A binding protein p300, KAT3B, MKHK2, p300, p300 HAT, RSTS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ep300 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBiD homology domain
- SMAD binding
- histone acetyltransferase domain
- interferon-binding domain
- smad binding domain
- Histone acetylation protein
- androgen receptor binding
- transcription factor binding
- Bromodomain
- cell cycle regulatory domain
- KIX domain
- receptor binding domain
- TAZ zinc finger
- ZZ
- histone acetyltransferase
- ligand-dependent nuclear receptor interactor
- PSPD domain
- protein kinase binding
- beta-catenin binding
- nucleic acid binding
- CR2 domain
- antigen binding
- CH1 domain
- protein binding
- sequence-specific DNA binding
- c-Jun binding domain
- N-acetyltransferase
- CH2 domain (from immunoglobulin)
- PHD finger superfamily
- cysteine-histidine rich domain
- acetyltransferase
- CH3 domain
- transcription regulator
- LXXLL motif
- transcription co-activator
- Ada2 homology domain
- RING_CBP-p300
- transcription activation domain
- chromatin binding
- Creb binding
- enzyme
- glutamine-rich domain
- peroxisome proliferator activated receptor binding
- CH2 domain
- Tax/creb binding domain
- CREB binding domain
- N-acyltransferase
- NF-kappaB binding
- central domain
- p53 binding
- transferase, transferring acyl groups
- DNA binding
- RNA binding
- binding protein
- damaged DNA binding
- lysine N-acetyltransferase
- double-stranded DNA binding
- adenovirus E1A binding domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the Ep300 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Hereditary Breast Cancer Signaling
- HIF1α Signaling
- Huntington's Disease Signaling
- Hypoxia Signaling in the Cardiovascular System
- Lymphotoxin β Receptor Signaling
- Maturity Onset Diabetes of Young (MODY) Signaling
- Melanocyte Development and Pigmentation Signaling
- NER Pathway
- NF-κB Signaling
- NRF2-mediated Oxidative Stress Response
- Nur77 Signaling in T Lymphocytes
- p53 Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Prolactin Signaling
- Renal Cell Carcinoma Signaling
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- TGF-β Signaling
- TR/RXR Activation
- VDR/RXR Activation
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- breast cancer
- acute lymphoblastic leukemia
- acute myeloid leukemia
- precursor B-cell acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
- malignant hematopoietic neoplasm
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- lung adenocarcinoma
role in cell
- expression in
- phosphorylation in
- cell viability
- binding in
- apoptosis
- growth
- activation in
- formation
- production in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- granules
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear rim
- nuclear speckles
- centromeres
- chromatin
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ep300 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of gluconeogenesis
- fat cell differentiation
- positive regulation of sequence-specific DNA binding transcription factor activity
- face morphogenesis
- regulation of androgen receptor signaling pathway
- learning or memory
- response to hypoxia
- peptidyl-lysine acetylation
- internal peptidyl-lysine acetylation
- positive regulation of transcription, DNA-dependent
- N-terminal peptidyl-lysine acetylation
- apoptotic process
- platelet formation
- positive regulation of neuron projection development
- positive regulation of protein import into nucleus
- positive regulation of gene expression, epigenetic
- B cell differentiation
- circadian rhythm
- positive regulation of JAK-STAT cascade
- organ morphogenesis
- cellular response to nutrient levels
- somitogenesis
- negative regulation of autophagy
- behavioral defense response
- regulation of autophagy
- macrophage derived foam cell differentiation
- regulation of mitochondrion organization
- positive regulation by host of viral transcription
- multicellular organism growth
- regulation of cellular response to heat
- nervous system development
- positive regulation of transcription from RNA polymerase II promoter
- stimulatory C-type lectin receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- cellular response to leucine
- thigmotaxis
- megakaryocyte development
- cellular response to UV
- negative regulation of protein complex assembly
- positive regulation of T-helper 17 cell lineage commitment
- lung development
- internal protein amino acid acetylation
- regulation of tubulin deacetylation
- protein acetylation
- regulation of glycolysis
- I-kappaB kinase/NF-kappaB cascade
- protein destabilization
- skeletal muscle tissue development
- protein stabilization
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- protein-DNA complex
- cytosol
- chromatin
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- transferase activity, transferring acyl groups
- H3 histone acetyltransferase activity
- acetyltransferase activity
- H2B histone acetyltransferase activity
- histone acetyltransferase activity (H3-K27 specific)
- transcription coactivator binding
- p53 binding
- chromatin DNA binding
- zinc ion binding
- histone acetyltransferase activity (H3-K18 specific)
- beta-catenin binding
- chromatin binding
- damaged DNA binding
- NF-kappaB binding
- lysine N-acetyltransferase activity
- histone acetyltransferase activity
- DNA binding
- transcription cofactor binding
- pre-mRNA intronic binding
- protein binding
- androgen receptor binding
- transcription coactivator activity
- tau protein binding
- peptide N-acetyltransferase activity
- H4 histone acetyltransferase activity