Wwp2 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; and regulation of DNA-templated transcription. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwp2 |
| Official Name | WW domain containing E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:1914144] |
| Ensembl ID | ENSMUSG00000031930 |
| Bio databases IDs | |
| Aliases | WW domain containing E3 ubiquitin protein ligase 2 |
| Synonyms | 1300010O06Rik, AIP2, LOC103690129, WW domain containing E3 ubiquitin protein ligase 2, WWp2-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wwp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- WW class I binding domain
- transcription factor binding
- enzyme
- protein binding
- potassium channel inhibitor
- WW domain
- xPPxY motif
- HECTc
- Domain with 2 conserved Trp (W) residues
- ubiquitin-protein transferase activity
- WW
- ion channel binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Wwp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- neoplasia
- schizophrenia
- myocardial infarction
- coronary artery disease
- knee osteoarthritis
- pancreatic cancer
- irritable bowel syndrome
- survival
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- K63 polyubiquitination in
- phosphorylation in
- transcription in
- production in
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wwp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- protein modification process
- transcription from RNA polymerase II promoter
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of Notch signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of protein transport
- extracellular transport
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of membrane potential
- negative regulation of transcription, DNA-dependent
- negative regulation of transporter activity
- regulation of ion transmembrane transport
- protein K63-linked ubiquitination
- protein ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- transcription factor binding