Oas1g Gene Summary [Mouse]

This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Details

Type
Protein Coding
Official Symbol
Oas1g
Official Name
2'-5' oligoadenylate synthetase 1G [Source:MGI Symbol;Acc:MGI:97429]
Ensembl ID
ENSMUSG00000066861
Bio databases IDs NCBI: 23960 Ensembl: ENSMUSG00000066861
Aliases 2'-5' oligoadenylate synthetase 1G
Synonyms 2',5'-oligoadenylate synthetase, 2'-5' oligoadenylate synthetase 1A, 2'-5' oligoadenylate synthetase 1G, L2, L3, Mmu-L, Mmu-L2, OAS-1, Oas1a, Oas1b, Oas1c, Oas1g, Oias-1
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oas1g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Second Messenger Oligonucleotide or Dinucleotide Synthetase domain
  • 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
  • Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
  • double-stranded RNA binding
  • enzyme
  • protein binding
  • 2'-5'-oligoadenylate synthetase

Pathways

Biological processes and signaling networks where the Oas1g gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • PAX6
  • Oas1c (includes others)
disease
  • early onset hypertension
  • insulin-dependent diabetes mellitus
regulated by
  • Immunoglobulin
  • doxorubicin
  • lipopolysaccharide
  • sulforafan
  • beta-estradiol
  • resveratrol
  • NPC1
  • cigarette smoke
  • IFNG
  • PLAU
regulates
  • purine nucleotide

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • ribosome
  • Nucleus
  • Mitochondria
  • cytosol
  • nucleoplasm

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.