Ifng Gene Summary [Mouse]
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ifng |
| Official Name | interferon gamma [Source:MGI Symbol;Acc:MGI:107656] |
| Ensembl ID | ENSMUSG00000055170 |
| Bio databases IDs | |
| Aliases | interferon gamma |
| Synonyms | If2f, IFG, IFI, IFN-2, IFNG2, IFN gamma, IFN-II, IFN type II, IFN-γ, IMD69, INF-γ, Interferon gamma, Interferon γ, type II INTERFERON, γ-ifn, γ interferon |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifng often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interferon-gamma receptor binding
- protein binding
- cytokine
- basic domain
- Interferon gamma
Pathways
Biological processes and signaling networks where the Ifng gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antigen Presentation Pathway
- Atherosclerosis Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- IL-7 Signaling Pathway
- Interferon Signaling
- MSP-RON Signaling Pathway
- Neuroprotective Role of THOP1 in Alzheimer's Disease
- Retinoic acid Mediated Apoptosis Signaling
- Role of BRCA1 in DNA Damage Response
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- T Helper Cell Differentiation
- Th1 Pathway
- Th2 Pathway
- VDR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- infection
- hypersensitive reaction
- epithelial cancer
- epithelial neoplasia
- cancer
- digestive system cancer
- abdominal cancer
- neoplasia
- autoimmune disease
role in cell
- cell death
- binding
- expression in
- phosphorylation in
- formation
- formation in
- inhibition
- acidification
- upregulation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- membrane surface
- apical cell surfaces
- plasma membrane extracellular face
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifng gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of smooth muscle cell apoptotic process
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- macrophage activation involved in immune response
- positive regulation of tyrosine phosphorylation of STAT protein
- JAK-STAT cascade
- regulation of insulin secretion
- negative regulation of transcription, DNA-dependent
- positive regulation of membrane protein ectodomain proteolysis
- humoral immune response
- apoptotic process
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- macrophage differentiation
- positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
- positive regulation of protein import into nucleus
- positive regulation of fructose 1,6-bisphosphate metabolic process
- positive regulation of inflammatory response
- negative regulation of beta-amyloid clearance
- positive regulation of calcidiol 1-monooxygenase activity
- adaptive immune response
- positive regulation of vitamin D biosynthetic process
- positive regulation of autophagy
- negative regulation of gene expression
- negative regulation of epithelial cell differentiation
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of gene expression
- positive regulation of neurogenesis
- positive regulation of interleukin-6 production
- positive regulation of phagocytosis
- positive regulation of nitric oxide biosynthetic process
- positive regulation of protein deacetylation
- positive regulation of cell proliferation
- extrinsic apoptotic signaling pathway
- response to virus
- positive regulation of glycolysis
- positive regulation of MHC class II biosynthetic process
- negative regulation of transcription from RNA polymerase II promoter
- astrocyte activation
- positive regulation of interleukin-23 production
- positive regulation of osteoclast differentiation
- negative regulation of smooth muscle cell proliferation
- regulation of metabolic process
- positive regulation of epithelial cell migration
- negative regulation of interleukin-17 production
- positive regulation of protein complex assembly
- interferon-gamma-mediated signaling pathway
- positive regulation of receptor activity
- cell surface receptor signaling pathway
- microglial cell activation
- positive regulation of interleukin-12 production
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
- positive regulation of killing of cells of other organism
- positive regulation of cytokine production
- positive regulation of protein serine/threonine kinase activity
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor binding
- cytokine activity