Plau Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Part of serine-type endopeptidase complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; hepatocellular carcinoma; and steatotic liver disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plau |
| Official Name | plasminogen activator, urokinase [Source:MGI Symbol;Acc:MGI:97611] |
| Ensembl ID | ENSMUSG00000021822 |
| Bio databases IDs | |
| Aliases | plasminogen activator, urokinase |
| Synonyms | ATF, BDPLT5, plasminogen activator, urokinase, QPD, UPA, uPA 50 kd form, UPA-H, UPAM, URK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plau often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- serine protease domain
- protein binding
- EGF-like domain
- protease domain
- receptor binding domain
- trypsin
- growth factor domain
- serine endopeptidase
- uPAR binding domain
Pathways
Biological processes and signaling networks where the Plau gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic steatohepatitis
- exudative age-related macular degeneration
- atherosclerosis
- heart failure
- hepatocellular carcinoma
- edema
- glioblastoma cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- fibrosis
role in cell
- production in
- expression in
- binding in
- proliferation
- phosphorylation in
- growth
- invasiveness
- migration
- apoptosis
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell-substratum contacts
- cell surface
- focal adhesions
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- tertiary granule membrane
- specific granule membrane
- apical membrane
- extracellular matrix
- cell membrane leading edge
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plau gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of wound healing
- negative regulation of fibrinolysis
- signal transduction
- regulation of smooth muscle cell-matrix adhesion
- regulation of fibrinolysis
- blood coagulation
- fibrinolysis
- regulation of cell proliferation
- regulation of cell adhesion mediated by integrin
- chemotaxis
- smooth muscle cell migration
- response to hypoxia
- negative regulation of plasminogen activation
- plasminogen activation
- proteolysis
- regulation of plasminogen activation
- regulation of receptor activity
- regulation of cell adhesion
- regulation of smooth muscle cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- external side of plasma membrane
- serine protease inhibitor complex
- extracellular region
- tertiary granule membrane
- plasma membrane
- cell surface
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity