ATP2C2 Gene Summary [Human]
Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATP2C2 |
| Official Name | ATPase secretory pathway Ca2+ transporting 2 [Source:HGNC Symbol;Acc:HGNC:29103] |
| Ensembl ID | ENSG00000064270 |
| Bio databases IDs | |
| Aliases | ATPase secretory pathway Ca2+ transporting 2, secretory pathway calcium ATPase 2 |
| Synonyms | 1810010G06Rik, ATPase, Ca++ transporting, type 2C, member 2, ATPase secretory pathway Ca2+ transporting 2, Ca-ATPase2, KIAA0703, mKIAA0703, SPCA2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATP2C2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- magnesium-translocating P-type ATPase
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- heavy metal translocating P-type ATPase
- enzyme
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- intracellular loop
- Ca2+-transporting ATPase
- cation-transporting ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- manganese ion transporter
- P-type ATPase
- K+-transporting ATPase, B subunit
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- age-related macular degeneration
- attention deficit hyperactivity disorder
- Hutchinson-Gilford progeria syndrome
- idiopathic inflammatory myopathy
- chronic obstructive pulmonary disease
- acute myeloid leukemia
regulates
- Ca2+
- heavy metal
role in cell
- tumorigenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- cytoplasmic face of plasma membrane
- microsome
- Golgi membrane
- trans Golgi network
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATP2C2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- manganese ion transport
- manganese ion transmembrane transport
- calcium ion transmembrane transport
- mammary gland epithelium development
- protein localization in plasma membrane
- cellular calcium ion homeostasis
- positive regulation of calcium ion import
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasmic vesicle
- Golgi membrane
- endoplasmic reticulum
- basolateral plasma membrane
- trans-Golgi network membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- metal ion binding
- calcium-transporting ATPase activity