AMELY Gene Summary [Human]
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | AMELY |
| Official Name | amelogenin Y-linked [Source:HGNC Symbol;Acc:HGNC:462] |
| Ensembl ID | ENSG00000099721 |
| Bio databases IDs | |
| Aliases | amelogenin Y-linked |
| Synonyms | amelogenin Y-linked, AMGL, AMGY |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMELY often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of tooth enamel
- protein binding
- Amelogenin
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMELY gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- enamel mineralization
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- structural constituent of tooth enamel