CRISPLD2 Gene Summary [Human]
Predicted to enable glycosaminoglycan binding activity. Involved in face morphogenesis. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CRISPLD2 |
| Official Name | cysteine rich secretory protein LCCL domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25248] |
| Ensembl ID | ENSG00000103196 |
| Bio databases IDs | |
| Aliases | cysteine rich secretory protein LCCL domain containing 2, late gestation lung 1 |
| Synonyms | 1810049K24Rik, coffeecrisp, CRISP11, cysteine-rich secretory protein LCCL domain containing 2, DKFZp434B044, LCRISP2, LGL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CRISPLD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- LCCL domain
- heparin binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- transport vesicles
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CRISPLD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
- face morphogenesis
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule lumen
- extracellular matrix
- transport vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- heparin binding