Crispld2 Gene Summary [Mouse]
Enables heparin binding activity. Acts upstream of or within extracellular matrix organization. Located in extracellular matrix. Is expressed in several structures, including gut; metanephros; pituitary gland; respiratory system; and submandibular gland primordium. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crispld2 |
| Official Name | cysteine-rich secretory protein LCCL domain containing 2 [Source:MGI Symbol;Acc:MGI:1926142] |
| Ensembl ID | ENSMUSG00000031825 |
| Bio databases IDs | |
| Aliases | cysteine-rich secretory protein LCCL domain containing 2 |
| Synonyms | 1810049K24Rik, coffeecrisp, CRISP11, cysteine-rich secretory protein LCCL domain containing 2, DKFZp434B044, LCRISP2, LGL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crispld2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains
- CAP
- LCCL domain
- heparin binding
- glycosaminoglycan binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- transport vesicles
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crispld2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
- face morphogenesis
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule lumen
- extracellular matrix
- transport vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- heparin binding