CEACAM8 Gene Summary [Human]
Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CEACAM8 |
| Official Name | CEA cell adhesion molecule 8 [Source:HGNC Symbol;Acc:HGNC:1820] |
| Ensembl ID | ENSG00000124469 |
| Bio databases IDs | |
| Aliases | CEA cell adhesion molecule 8 |
| Synonyms | CD66b, CD67, CEA cell adhesion molecule 8, CGM6, NCA-95 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEACAM8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- protein heterodimerization
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- septic shock
- primary myelofibrosis
- severe sepsis
- osteomyelitis
- aortic valve calcification
- sepsis
- severe acute respiratory syndrome
- tuberculosis
regulated by
- dexamethasone
- lipopolysaccharide
- TNF
- Immunoglobulin
- tamibarotene
- nexinhib4
- Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-bombesin (6-14)
- IgG2a
- 2,2',4,4'-tetrabromodiphenyl ether
- semaxinib
regulates
- ERK1/2
role in cell
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEACAM8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- heterophilic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- azurophil granule membrane
- plasma membrane
- tertiary granule membrane
- specific granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity