CHRNA10 Gene Summary [Human]
Predicted to enable acetylcholine-gated cation-selective channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in cholinergic synapse and neuron projection. Predicted to be integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CHRNA10 |
| Official Name | cholinergic receptor nicotinic alpha 10 subunit [Source:HGNC Symbol;Acc:HGNC:13800] |
| Ensembl ID | ENSG00000129749 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic alpha 10 subunit, acetylcholine receptor, nicotinic, alpha 10 (neuronal) |
| Synonyms | Alpha10 nachr, cholinergic receptor nicotinic alpha 10 subunit, cholinergic receptor, nicotinic, alpha polypeptide 10, cholinergic receptor nicotinic α 10 subunit, cholinergic receptor, nicotinic, α polypeptide 10, Nachr α 10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHRNA10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- receptor binding
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the CHRNA10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- succinylcholine
- doxacurium
- enflurane
- cisatracurium
- isoflurane
- pipecuronium
- arecoline
- mecamylamine
- mivacurium
- pancuronium
disease
- chronic obstructive pulmonary disease
- Alzheimer disease
- morbid obesity
- schizophrenia
- depressive disorder
- nicotine withdrawal syndrome
- postoperative pain
- COVID-19
- nicotine dependence
- morphine-like drug dependence
regulated by
- Chrna7
- Alpha-conotoxin PeIA
- NRG (family)
- enflurane
- pancuronium
- cisatracurium
- pipecuronium
- D-tubocurarine
- atracurium
- ABT-089
role in cell
- proliferation
- phosphorylation in
- function
- abnormal morphology
- synaptic transmission
- elevation in
- innervation
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptic membrane
- synapse
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHRNA10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- ion transmembrane transport
- synaptic transmission
- regulation of cell proliferation
- elevation of cytosolic calcium ion concentration
- regulation of membrane potential
- negative regulation of ERK1 and ERK2 cascade
- inner ear morphogenesis
- calcium ion transmembrane transport
- response to auditory stimulus
- membrane depolarization
- detection of mechanical stimulus involved in sensory perception of sound
Cellular Component
Where in the cell the gene product is active
- membrane
- synapse
- perikaryon
- neuron projection
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- acetylcholine-gated cation channel activity
- calcium channel activity
- receptor binding