KCNK13 Gene Summary [Human]
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | KCNK13 |
| Official Name | potassium two pore domain channel subfamily K member 13 [Source:HGNC Symbol;Acc:HGNC:6275] |
| Ensembl ID | ENSG00000152315 |
| Bio databases IDs | |
| Aliases | potassium two pore domain channel subfamily K member 13 |
| Synonyms | BB085247, F730021E22Rik, Gm1570, Gm1685, K2p13.1, potassium channel, subfamily K, member 13, potassium two pore domain channel subfamily K member 13, prdx1, THIK-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNK13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- protein binding
- identical protein binding
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell periphery
- outer membranes
- cellular membrane
- myelinated nerve fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNK13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- outward rectifier potassium channel activity
- potassium ion leak channel activity