ZFYVE28 Gene Summary [Human]
Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZFYVE28 |
| Official Name | zinc finger FYVE-type containing 28 [Source:HGNC Symbol;Acc:HGNC:29334] |
| Ensembl ID | ENSG00000159733 |
| Bio databases IDs | |
| Aliases | zinc finger FYVE-type containing 28, lateral signaling target-2 homolog |
| Synonyms | 9630058O20Rik, Gm146, LST2, LYST2, mKIAA1643, zinc finger, FYVE domain containing 28, zinc finger FYVE-type containing 28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFYVE28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- Protein present in Fab1, YOTB, Vac1, and EEA1
- ubiquitination site
- PHD finger superfamily
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- schizophrenia
- cervical cancer
- androgenic alopecia
- obesity
- insulin resistance
- Alzheimer disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- cervical carcinoma
- epithelial uterine cancer
regulated by
- NOTCH1
- PD98059
- insulin
- sapanisertib
- corticosterone
role in cell
- expression in
- degradation in
- signaling in
- conversion in
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFYVE28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epidermal growth factor-activated receptor activity
- negative regulation of epidermal growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphatidylinositol-3-phosphate binding