DRGX Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including detection of temperature stimulus; nervous system development; and sensory perception of mechanical stimulus. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DRGX |
| Official Name | dorsal root ganglia homeobox [Source:HGNC Symbol;Acc:HGNC:21536] |
| Ensembl ID | ENSG00000165606 |
| Bio databases IDs | |
| Aliases | dorsal root ganglia homeobox, paired-like homeodomain trancription factor DRG11 |
| Synonyms | dorsal root ganglia homeobox, DRG11, PRRXL1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRGX often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- OAR motif
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- juvenile rheumatoid arthritis
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
role in cell
- differentiation
- development
- migration
- abnormal morphology
- guidance
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRGX gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- trigeminal nerve development
- dorsal spinal cord development
- detection of chemical stimulus
- axon guidance
- sensory perception of mechanical stimulus
- detection of temperature stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity